2008 Barcelona - European Society of Human Genetics

Prenental diagnostics
T21 samples showed significant changes, with similarities to the protein
profile of normal first trimester pregnancies. Two protein peak masses
in the ranges 5-10kDa (p=0 .028) and 20-25kDa (p=0 .004) were more
than 2 fold different. The 2D DiGE first trimester study revealed two
spots in the 5 .3-6 .5 pH range, increased by 1 .4 fold (p=0 .019) and
1 .2 fold (p=0 .017) . Analysis of second trimester samples showed two
further significant spots in the 5.3-6.5 pH range and two in the 6-9 pH
range (p