PEC12-25 CAPEC-PROCESS Industrial Consortium ... - DTU Orbit

industry and work is carried out at three levels, namely: laboratory scale experimental
process evaluation; model based evaluation of process technology and pilot-scale process
validation. Two demonstration units operate in the pilot facilities (both for immobilized and
soluble enzyme reactions at 10-20L scale). Using the results from work at the three levels
enables new technology and processes to be evaluated both experimentally and also from
the perspective of implementation, including eceonomic and environmental evaluation. The
research is divided into 6 research area:
Main research areas:
1. Micro processes – the development of miniaturised unit operations and processes, both to
collect data rapidly and in parallel of use for modelling and also to develop process
screening tools.
2. Continuous processes – the development of new continuous or semi-continuous
processes form batch. New concepts are developed including the creation of gereic process
plant.
3. Biocatalytic processes – the development of enzymes (and whole-cell) based processes
where high selectivity and mild conditiopns are required. The focus is especially on multienzymatic
and chemo-enzymatic processes. Downstream processing and product recovery
are integrated in all processes.
4. Process intensification and intensified unit operation – development of integrated unit
operations (e.g. ISPR) and methods and tools for assessing new operations and processes
operating at an intensified level.
5. Process Analytical Technologies (PAT) – development of monitoring and control
techniques to allow on-line adjustment of process parameters such that product quality can
be maintained. Particular focus is on the phramacutical industry (where the FDA drive such
changes).
6. Scale translation – development of techniques for predicting scale-up and scale-down of
processes and we as experimental validation.
The PROCESS Center is involved in the following large collaborative projects in Denmark
and in Europe:
• Sustainable Biodiesel is a project established in 2008 with the Danish National
Advanced Technology Foundation, DTU Management, Novozymes A/S, Aarhus
University and Emmelev A/S. It is focused on developing a new enzymatic route to
biodiesel.
• Towards Robust Fermentation Processes by Targeting Population Heterogeneity at
Microscale is a project established in 2009 with the Danish Council for Strategic
Research, DTU Systems Biology, DTU Fotonik, Department of Biology (University of
Copenhagen), Department of Biotechnology, Chemistry and Environmental
Engineering (Aalborg University), Crystal Fibre A/S, Fermenco ApS and Foss A/S. It is
focused on characterization and control of the heterogeneity of a population of
microorganisms in a fermentation.
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