PEC12-25 CAPEC-PROCESS Industrial Consortium ... - DTU Orbit

CAPEC
Joana de Lima Ramos (JLR)
PROCESS
Noor Asma Fazli Bin Abdul
Samad (NAS)
.
This project aims to introduce a paradigm shift in productprocess
design through the application of CAPE/PSE tools in
these industries. The research will focus on the use of validated
models in the early stages of product-process design in order to
eliminate redundant alternative process routes.
The objective will be to identify the most promising process
route so that the more time consuming and costly steps
(computational as well as experimental) can be reduced.
To achieve this objective, a systematic framework for
Computer-Aided Flowsheet Synthesis and Design (CAFD) will
be developed and evaluated in collaboration with Alfa Laval. A
particular emphasize will be given to deal with uncertainties in
data and models.
Supervisors: GSI, RaG, Bent Sarup (Alfa Laval)
Start: 01-06-2010; End: 31-05-2013
Research area: B, C, E
Guiding biocatalytic process improvements using engineering
evaluation tools
Biocatalysis is an emerging area of technology and to date few
reports have documented the economics or environmental
profile of such processes
During the development of a biocatalytic process and in
particular during its scale-up, there are several required
considerations. Two of the most important are the economic and
environmental profile. The present project is focused on the
development of engineering tools in order to assist a fast and
accurate economic and environmental analysis. When applied to
a given process these have a decisive role in helping to identify
bottlenecks in process development, and to justify where to put
effort and resources. Further, to exemplify the methodology,
guidelines for the successful biocatalytic production of chiral
amines using transaminases will be identified through process
economic and environmental assessment.
The outcome of the present research will establish new tools and
knowledge useful in biocatalysis and (bio-) process
development.
Supervisors: JW, PT
Start: 01-03-2010; End: 01-03-2013
Collaborations: Evonik, DSM, Lonza
Control of process operations and monitoring of product
qualities through hybrid multi-scale model-based analysis
A generic multi-dimensional model-based framework of batch
crystallization processes has been developed covering a wide
range of crystallization models and operational scenarios. In
order to control and monitor the crystallization operations and to
ensure that the desired crystal size distribution (CSD) is
achieved, an appropriate Process Analytical Technology (PAT)
system (= set of appropriate monitoring tools + actuators) needs
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