PEC12-25 CAPEC-PROCESS Industrial Consortium ... - DTU Orbit

CAPEC-PROCESS
Aleksandar Mitic (ASMI)
PROCESS
Igor Mitrofanov (IGM)
.
breakage and agglomeration and a population balance model is
based on the phenomena allowing calculation of the multidimensional
crystal size distribution (CSD). The translation of
measured data for monitoring of crystallization operations is
used for model parameters and the full model with parameters is
used for analysis of the crystallization process through
simulation within a framework describing the balance equations.
With the simulations different operational policies and process
options are explored through generation of the CSD for the
systems. An operational policy for the desired crystal size
distribution for a given crystallization process is designed.
Supervisors: RaG, KVG, NvS
Start: 01-03-2011; End: 28-02-2014
Research area: B, C, D
Operational aspects of continuous pharmaceutical production
Most pharmaceutical productions are based on batch and semibatch
processes and involves many problems, such as long
reaction sequences, non-uniform conditions inside vessels,
implementation of PAT applications. Continuous manufacturing
might offer a solution to those problems. Therefore, the main
focus of this PhD project is to develop efficient continuous
production of zuclopenthixol, a product of H. Lundbeck A/S. A
grignard reaction, hydrolysis and a dehydration reaction should
all work in continuous mode with high selectivity in order to
avoid intermediate crystallization steps. Simplifications and
improvements of the liquid-liquid separation, as well as
acceleration of the slow hydroamination reaction are additional
challenges. Potential use of micro-scale equipment, such as
microreactors and L-L microseparators will be tested. Also, online
monitoring and control of the established continuous
process will be studied. Applications of NIR spectroscopy will
be tested.
Supervisors: KVG, Kim Dam-Johansen (CHEC)
Start: 15-11-2010; End: 14-11-2013
Research area: continuous pharmaceutical production, PAT,
microreactor technology
A methodology for systematic design and selection of green
solvents for increased yield in organic reactions
Methodology for selection and design of single organic
reactions has previously been developed at CAPEC (Gani et al,
Computers and Chemical Engineering, 2005, 2008). This
methodology is based on a rule-based algorithm. However, the
methodology is applicable only to organic chemicals that are
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