PEC12-25 CAPEC-PROCESS Industrial Consortium ... - DTU Orbit

3.4 PhD-Research Project Overview
Naweed Al-Haque (NAH)
PROCESS-CAPEC
Vijaya Krishna Bodla (ViKB)
PROCESS
Modelling of controlled substrate supply using solid sorbents
in biocatalysis
With the development of biocatalysts, greener technologies have
become more accessible to industry. The obvious advantage of
this technology is selectivity which is necessary to obtain a high
yield of a specific product. The other advantages of operating in
benign operating conditions make it an alternative worth
investigating. However In bioprocesses, especially in
bioconversions, the substrate and the product may inhibit or
damage the biological catalyst or interfere with other
components in the reaction medium above a critical
concentration. This limitation can be overcome with methods
such as in-situ product removal (ISPR) and in-situ substrate
supply (ISSS) using solid sorbents. This project will focus on
the latter issue and in particular for the development of this
novel substrate release technique with controlled diffusing rate
of the substrate in the reaction medium using a solid resin(s).
Supervisors: JW; PT; RaG
Start: 1-11-2009; End: 14-11-2012
Research area: Biocatalysis, controlled substrate supply, resins,
ISPR, mathematical modelling
Integrated microfactories for enzyme production
This project aims to demonstrate that fermentation and
biocatalysis can be integrated into a novel leaner and greener
process. The hypothesis is to construct and operate integrated
microscale reactors using transaminase model system (adapted
to specific microorganism and the biocatalytic reaction) in an
intensified and more efficient process also for scaling-up. It is
the intention to use an integrated microfactory to quickly and
effectively screen for different process conditions. The proposed
microfactory has a number of features that are advantageous for
large-scale production with respect to improved economy of the
proposed process: (1) the method for preparing the catalyst is
considerably cheaper as no intermediary purification steps are
needed; (2) the system process intensity is inherently enhanced
through the continuous operation; (3) large hydrophobic
substrates would be easily accessible since the cell membranes
are lysed.
Supervisors: KVG,ULKR,JW
Start: 01-03-2011; End: 28-02-2014
Research area: Microreactors; Biocatalysis
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