PEC12-25 CAPEC-PROCESS Industrial Consortium ... - DTU Orbit

CAPEC
Supervisor: RaG, P Crafts (AZ)
Start: 01-03-2011; End: 29-02-2012
PROCESS
Pär Tufvesson (PT)
Ulrika Törnvall (ULRT)
aqueous solubility. They can also be used to avoid a solid
dose form and the solid state issues that often blight this
category.
The aim of the project is to develop a software tool to predict
the thermodynamic solubility of drug molecules in high
molecular weight liquids
Research area: A, C
Biocatalytic production of chiral amines using
transaminases
Project Description: Biocatalytic transamination is being
established as key tool for the production of chiral amine
pharmaceuticals and precursors due to its excellent
enantioselectivity as well as green credentials. Recent
examples demonstrate the potential for developing
economically competitive processes using a combination of
modern biotechnological tools for improving the biocatalyst
alongside using process engineering and integrated separation
techniques for improving productivities. However, many
challenges remain in order for the technology to be more
widely applicable, such as technologies for obtaining high
yields and productivities when the equilibrium of the desired
reaction is unfavorable. The current project adresses these
process challenges and develop strategies to overcome them,
and aim to understand these and their applicability based on
fundamental principles.
Research area: Process evaluation, Biocatalysis
Development of the next generation biocatalysts for
industrial production of chemicals
A major hurdle for a widespread implementation of
biocatalysis in industry is the lack of appropriate process
technology, especially in fields where extra demands are
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