2012 Program Booklet - MCD Biology - University of Colorado Boulder

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Jennifer Leeds, PhD Executive Director-‐ Antibacterial Discovery Infectious Diseases Area Novartis Institute for BioMedical Research Title: Discovery and development of LFF571, a novel antibacterial for the treatment of C. difficile infection. Friday, October 12 6.10-‐6.55 pm JSCBB Butcher Auditorium Abstract: Antibiotics are among the most important advances in the history of modern medicine. Antibiotics transform deadly bacterial infections into curable diseases, and enable surgical and medical innovation in nearly every therapeutic area. However, the increasing use of antibiotics has contributed to the rise in drug resistant and multi-‐drug resistant pathogens both in the community and in the hospital setting. At the same time, the number of new agents to treat bacterial infections is diminishing, partly due to the difficulty in identifying ideal targets and chemical starting points as well as increasing challenges in treating patients with complex medical needs. New agents should be potent against organisms exhibiting clinically-‐ relevant drug resistant phenotypes. The discovery of new chemical entities targeting unexploited mechanisms of growth inhibition is one strategy to address this hurdle. This was the origin of the drug discovery program that led us to discover LFF571. LFF571 is a new chemical entity that is currently being evaluated for safety and efficacy in patients with Clostridium difficile infection. The discovery and early development program for this novel compound will be presented.
Keynote Speaker: Larry Gold, PhD Chairman, Founder, and CEO of SomaLogic Founder of NeXstar and Synergen Title: Empowering Students: The Good and the Ugly Saturday, October 13 9:00 – 9:30 am JSCBB Butcher Auditorium Abstract: In 1973 or thereabouts Charlie Yegian died of leukemia. Charlie was a young professor in MCDB, he was my friend, and I missed him immediately and still miss him. He was a great teacheer. Jane Westlye and I arranged a Symposium to honor Charlie. It was a great Symposium. One of the speakers said about Charlie that "when he did an experiment it stayed done." There is no higher accolade for a scientist. I then had an idea, which was simple. We could continue to have Symposia like the one we had to honor Charlie, and I could help the students raise money (my specialty, apparently) and they could do the work and share the learning that came with putting on a science symposium. We have had great student-‐driven symposia and some that were just OK -‐ that is as it should be. We always have had good people come to speak. The tension (The Good and the Ugly") is built into the activity, and it has to be there. Students are young, and they have ideas that are, say, in progress -‐ that has to be there. Students posture, unlike faculty, who never posture.
Page 1 and 2: 26 TH MCDB Graduate Student Symposi
Page 3 and 4: Past MCDB Graduate Student Symposia
Page 5: Keynote Speaker: William Freytag, P
Page 9 and 10: William S. Marshall, PhD President
Page 11 and 12: JoAnne Flynn, PhD Professor, Depart
Page 13 and 14: Jeffrey Settleman, PhD Senior Direc
Page 15 and 16: William Sullivan, PhD Professor, De
Page 17 and 18: Symposium Location Jennie Smoly Car
Page 19 and 20: 2012 PRESENTING SPONSORS Arts and S

2012 Program Booklet - MCD Biology - University of Colorado Boulder

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