2012 Program Booklet - MCD Biology - University of Colorado Boulder

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Steven A. Williams, PhD Chief Medical Officer SomaLogic Title: The Voices of Life; Discovery of Protein Patterns in Health and Disease Using SOMAmers Saturday, October 13 11:20 – 12:05 pm JSCBB Butcher Auditorium Abstract: Despite the exciting promises being made about personalized medicine enabled by genetic testing, it is an impossible task. This is because the environment is not genetic, and yet has a big (or perhaps I should say "supersize") influence on health and disease, and because outside of a cancer our genetics don't significantly change from the time when we are babies to the day we die. The ideal health measurement would be of low cost and would respond to both environment and changes in health status. Proteins -‐ as the downstream product of genetics and environment -‐ have the right characteristics but the available technologies have not been up to the task of measuring thousands of them across a difference in abundance from the lowest to the highest of tens of billions to one. A new type of reagent will be described -‐ the SOMAmer -‐ which has enabled us to overcome these issues, and which has driven unprecedented discoveries. Examples will be shown from the early detection of cancer! to cardiovascular disease, and how individual tests can be bundled together to enable the "wellness chip", with the intention of lowering the cost of healthcare and improving health outcomes.
JoAnne Flynn, PhD Professor, Department of Microbiology and Molecular Genetics University of Pittsburgh School of Medicine Title: Tuberculosis: Seeing is Believing Saturday, October 13 1:15 – 2:00 pm JSCBB Butcher Auditorium Abstract: Tuberculosis is caused by Mycobacterium tuberculosis. Humans infected with this bacillus can present with active TB (symptomatic) or clinically latent (asymptomatic) infection. The factors that determine the outcome of infection are not fully understood. Active TB can present in a variety of ways, from mild to fulminant disease. Recently, we have proposed that latent infection also represents a spectrum of infections, and those that are “higher” on the spectrum of latency are more likely to develop reactivation TB. Using a non-‐human primate model of tuberculosis, we have assessed the factors and events that influence outcome of infection, and have used sophisticated whole-‐body imaging to track the infection. Our findings indicate that the spectrum of M. tuberculosis infection that exists in the population can also exist in a single host. Using imaging, immunology, bacteriology and modeling, we have data to demonstrate the heterogeneity of infection within a single host at the level of the granuloma. Data on the variability in granulomas will be presented. This variability has implications for development of drugs to effectively and efficiently treat tuberculosis, as well as vaccines to prevent infection or disease.
Page 1 and 2: 26 TH MCDB Graduate Student Symposi
Page 3 and 4: Past MCDB Graduate Student Symposia
Page 5 and 6: Keynote Speaker: William Freytag, P
Page 7 and 8: Keynote Speaker: Larry Gold, PhD Ch
Page 9: William S. Marshall, PhD President
Page 13 and 14: Jeffrey Settleman, PhD Senior Direc
Page 15 and 16: William Sullivan, PhD Professor, De
Page 17 and 18: Symposium Location Jennie Smoly Car
Page 19 and 20: 2012 PRESENTING SPONSORS Arts and S

2012 Program Booklet - MCD Biology - University of Colorado Boulder

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