Strategy For Limiting Risks Human Health Draft of ... - ECHA - Europa
Strategy For Limiting Risks Human Health Draft of ... - ECHA - Europa
Strategy For Limiting Risks Human Health Draft of ... - ECHA - Europa
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Table 2.7: Ranking <strong>of</strong> health risks for workers (dermal contact) (1)<br />
Exposure scenario<br />
3. Use in other<br />
industries<br />
4.<br />
Abrasives, grinding<br />
discs<br />
EASE, analogous<br />
data<br />
2. Aluminium industry<br />
1. Production <strong>of</strong><br />
synthetic cryolite<br />
dust, granules<br />
(1)<br />
2.2 Consumers<br />
Exposure level<br />
in mg/kg/day<br />
Repeated dose<br />
toxicity,<br />
systemic effects:<br />
fluorosis,<br />
Developmental<br />
toxicity<br />
Critical exposure level in mg/kg/day<br />
1.3 7.1<br />
43 iii iii<br />
3.6 iii ii<br />
1.2 ii ii<br />
0.6 ii ii<br />
Exposure <strong>of</strong> consumers to cryolite occurs via inhalation through use <strong>of</strong> glazes in pottery. <strong>For</strong><br />
the use <strong>of</strong> powdery cryolite the modelled data by EASE estimation without local exhaust<br />
ventilation was selected with considering a duration <strong>of</strong> 1 hour an inhalation exposure <strong>of</strong> 6.25<br />
mg/m 3 .<br />
The bioavailibility is estimated as 100 % after inhalation.<br />
Acute toxicity<br />
<strong>Human</strong> data on the acute toxicity <strong>of</strong> cryolite are not available.<br />
Inhalation<br />
In a well conducted and guideline-compliant rat inhalation study, a LC50 <strong>of</strong> 4470 mg/m3 was<br />
derived. Therefore, a classification as harmful and labelling with R20 is appropriate. Taken<br />
into account the exposure value <strong>of</strong> 6.25 mg/m3 derived from a worst case scenario the margin<br />
<strong>of</strong> safety is judged to be sufficient.<br />
29
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