Strategy For Limiting Risks Human Health Draft of ... - ECHA - Europa

More documents

Recommendations

Info

Table 2.6: Ranking of health risks for workers (inhalation) Exposure scenario 3. Use in other industries 1. Production of synthetic cryolite dust 2. Aluminium industry Exposure level in mg/m³ 1. Production of synthetic cryolite granules 4. Abrasives, grinding discs EASE Abrasives, grinding discs analogous data (1) blank fields: conclusion ii Repeated dose toxicity, local effects Repeated dose toxicity, systemic effects: fluorosis Critical exposure level in mg/m 3 Developmental effects 0.1 1 5 10 iii iii iii 5 iii iii 2 iii iii 1 iii 1 iii 0.1 borderline iii 28 borderline iii borderline iii
Table 2.7: Ranking of health risks for workers (dermal contact) (1) Exposure scenario 3. Use in other industries 4. Abrasives, grinding discs EASE, analogous data 2. Aluminium industry 1. Production of synthetic cryolite dust, granules (1) 2.2 Consumers Exposure level in mg/kg/day Repeated dose toxicity, systemic effects: fluorosis, Developmental toxicity Critical exposure level in mg/kg/day 1.3 7.1 43 iii iii 3.6 iii ii 1.2 ii ii 0.6 ii ii Exposure of consumers to cryolite occurs via inhalation through use of glazes in pottery. For the use of powdery cryolite the modelled data by EASE estimation without local exhaust ventilation was selected with considering a duration of 1 hour an inhalation exposure of 6.25 mg/m 3 . The bioavailibility is estimated as 100 % after inhalation. Acute toxicity Human data on the acute toxicity of cryolite are not available. Inhalation In a well conducted and guideline-compliant rat inhalation study, a LC50 of 4470 mg/m3 was derived. Therefore, a classification as harmful and labelling with R20 is appropriate. Taken into account the exposure value of 6.25 mg/m3 derived from a worst case scenario the margin of safety is judged to be sufficient. 29
Page 1 and 2: TRISODIUM HEXAFLUOROALUMINATE (Cryo
Page 3 and 4: CONTENT 0 SUMMARY 5 1 BACKGROUND 7
Page 5 and 6: 0 Summary Trisodium hexafluoroalumi
Page 7 and 8: 1 Background In the framework of EU
Page 9 and 10: By-production in aluminium smelters
Page 11 and 12: Company Location(s) Alcoa Aviles Sp
Page 13 and 14: Table 2.1: Occupational exposure le
Page 15 and 16: Comparison of MOS and reference MOS
Page 17 and 18: Repeated dose toxicity Local effect
Page 19 and 20: was established at 0.5 mg/m 3 (6h/d
Page 21 and 22: Combined exposure For all exposure
Page 23 and 24: Developmental toxicity Cryolite was
Page 25 and 26: Table 2.4 Developmental toxicity, p
Page 27: Tables 2.6 (inhalation) and 2.7 (de
Page 31 and 32: Respiratory tract Regarding the sen
Page 33 and 34: and the analog sodium fluoride (NTP
Page 35 and 36: 3 Current Risk Reduction Measures C
Page 37 and 38: Country OEL (mg/m 3 STEL ) (mg/m 3
Page 39 and 40: 4 Possible Further Risk Reduction M
Page 41 and 42: Scenario 2: Use of cryolite in the
Page 43 and 44: Technical and organisational measur
Page 45: 6 Further Risk Reduction Measures R

Strategy For Limiting Risks Human Health Draft of ... - ECHA - Europa

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?