High-quality active ingredients are fi lled at the Supply Center in Bergkamen. 20 Product Supply
<strong>Bayer</strong> <strong>HealthCare</strong> manufactures products at almost 60 sites around the world which are managed by Product Supply. The production of active ingredients for prescription medicines is conducted primarily at the production sites in Wuppertal and Bergkamen (Germany) and Berkeley and Emeryville (united States). They are processed and packaged as finished pharmaceuticals in plants around the world. A broad spectrum of different pharmaceutical presentations is covered: solid formulations such as tablets, sugar-coated tablets and powders, semi-solid ointments and creams, and liquid drug products for application, for example, as injections or infusions. Hormonal contraceptives are produced as sugar- or film-coated tablets but also, for example, as intrauterine systems. These formulation and packaging activities are based in Berlin, Leverkusen and Weimar (Germany), Garbagnate (Italy), Turku (Finland), São Paulo (Brazil), Beijing (China), as well as various other sites in Europe, Asia and Latin America. Kogenate, a drug product for the treatment of hemophilia, is manufactured in Berkeley (United States) using a biotechnology process, while Betaferon/Betaseron for the treatment of multiple sclerosis is produced in Emeryville (United States). The main production sites for non-prescription (over-the-counter) drug products are located in Bitterfeld-Wolfen and Grenzach-Wyhlen (Germany), Cimanggis (Indonesia), Lerma (Mexico), Myerstown (United States) and Madrid (Spain). The globally marketed animal health products are mainly manufactured at the sites in Kiel (Germany) and Shawnee (United States). In addition to drug products for humans and animals, medical devices for diagnosis and therapy are produced in the United States. <strong>Bayer</strong> <strong>HealthCare</strong> supplies a total of more than 20,000 articles. The reason for this large number is the different presentations of individual products and packaging – for example, different formulations, dosages, pack sizes and language versions. <strong>Bayer</strong> <strong>HealthCare</strong> Product Supply steers the subgroup’s entire supply chain, from raw material sourcing through manufacturing to distribution, utilizing a global production network consisting of its own sites and those of contract manufacturers. In this way the company aims for continuous improvement of costs, flexibility and delivery reliability, maintaining high standards of quality, health, safety and environmental protection on a global basis. The manufacture of pharmaceutical products is subject to extraordinarily stringent quality standards. These standards are known collectively as “Good Manufacturing Practice” (GMP). Compliance with these requirements is regularly audited by internal experts, regulatory authorities and external consultants. ProDuCT SuPPly 21