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expertise. The current R&D focus in blood glucose<br />

monitoring includes ease-of-use, meter accuracy,<br />

and software to simplify data capture and analysis. In<br />

radiology and interventional, the division is focused on<br />

investments in informatics, contrast media, fluid delivery<br />

systems, interventional therapeutic catheters and other<br />

accessories to deliver innovative integrated solutions to<br />

customers. R&D activities focus on contrast agents for<br />

high field MRI and low radiation CT; solutions to improve<br />

diagnostic outcome and radiology workflow efficiency;<br />

equipment service; and vascular intervention systems for<br />

treating constricted or blocked blood vessels. The<br />

division’s expanded global network of leading clinical<br />

researchers supports R&D activities through innovative<br />

clinical studies.<br />

Research and development in the Animal Health Division<br />

is concentrated on the identification and registration of<br />

new active ingredients for applications in companion<br />

and farm animals. Another priority is the development of<br />

innovative formulations and new applications for existing<br />

research and Development Projects (Phase iii)*<br />

Aflibercept Treatment of diabetic macular edema<br />

active ingredients. The close collaboration with the re-<br />

search departments of <strong>Bayer</strong> <strong>HealthCare</strong> Pharma and<br />

<strong>Bayer</strong> CropScience offers a unique competitive advantage<br />

thanks to the opportunities to share data and<br />

research results. In all of <strong>Bayer</strong> Animal Health’s developments,<br />

the focus is always on user friendliness and<br />

safety for both humans and animals. The division’s main<br />

development sites are located in Monheim (Germany),<br />

Shawnee (USA) and Auckland (new Zealand).<br />

In the Analgesics category, <strong>Bayer</strong> Aspirin has been<br />

a leader in pain relief for over 110 years. The new <strong>Bayer</strong><br />

Advanced Aspirin represents the most exciting Aspirin<br />

innovation to date in the United States. Launched by the<br />

Consumer Care Division in 2011, the product was the<br />

result of more than five years of research and development<br />

and uses breakthrough patented technology to<br />

reduce the Aspirin particles into micro-particles. This<br />

next generation of Aspirin targets younger, more active<br />

consumers.<br />

Aflibercept Prevention of abnormal retinal angiogenesis following<br />

pathological myopia<br />

BAY 86-6150 (rFVIIa mutein) Treatment of hemophilia A (Phase II/III)<br />

BAY 94-9027 (rFVIII mutein) Treatment of hemophilia A<br />

Ciprofloxacin Inhale Treatment of pulmonary infections<br />

LCS-16 (ULD LnG Contraceptive System) Intrauterine contraception, duration of use: up to 5 years<br />

Prasterone ** Treatment of vulvovaginal atrophy<br />

Rivaroxaban Prevention of major adverse cardiac events (MACE)<br />

Sodium deoxycholate *** Injection for reduction of submental fat<br />

Sorafenib Treatment of breast cancer<br />

Sorafenib Treatment of liver cancer, adjuvant therapy<br />

Sorafenib Treatment of kidney cancer, adjuvant therapy<br />

Sorafenib Treatment of thyroid cancer<br />

Tedizolid Treatment of complicated skin and lung infections<br />

rESEArCH AnD DEvEloPMEnT<br />

* as of February 11, 2013<br />

** prasterone = vaginorm<br />

*** sodium deoxycholate =<br />

ATX-101<br />

The nature of drug discovery and<br />

development is such that not all<br />

compounds can be expected to<br />

meet the predefined project<br />

goals. It is possible that any or all<br />

of the projects listed above may<br />

have to be discontinued due to<br />

scientific and / or commercial<br />

reasons and will not result in<br />

commercialized products. It is also<br />

possible that the requisite Food<br />

and Drug Administration (FDA),<br />

European Medicines Agency<br />

(EMA) or other regulatory<br />

approvals will not be granted for<br />

these compounds.<br />

19

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