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expertise. The current R&D focus in blood glucose<br />
monitoring includes ease-of-use, meter accuracy,<br />
and software to simplify data capture and analysis. In<br />
radiology and interventional, the division is focused on<br />
investments in informatics, contrast media, fluid delivery<br />
systems, interventional therapeutic catheters and other<br />
accessories to deliver innovative integrated solutions to<br />
customers. R&D activities focus on contrast agents for<br />
high field MRI and low radiation CT; solutions to improve<br />
diagnostic outcome and radiology workflow efficiency;<br />
equipment service; and vascular intervention systems for<br />
treating constricted or blocked blood vessels. The<br />
division’s expanded global network of leading clinical<br />
researchers supports R&D activities through innovative<br />
clinical studies.<br />
Research and development in the Animal Health Division<br />
is concentrated on the identification and registration of<br />
new active ingredients for applications in companion<br />
and farm animals. Another priority is the development of<br />
innovative formulations and new applications for existing<br />
research and Development Projects (Phase iii)*<br />
Aflibercept Treatment of diabetic macular edema<br />
active ingredients. The close collaboration with the re-<br />
search departments of <strong>Bayer</strong> <strong>HealthCare</strong> Pharma and<br />
<strong>Bayer</strong> CropScience offers a unique competitive advantage<br />
thanks to the opportunities to share data and<br />
research results. In all of <strong>Bayer</strong> Animal Health’s developments,<br />
the focus is always on user friendliness and<br />
safety for both humans and animals. The division’s main<br />
development sites are located in Monheim (Germany),<br />
Shawnee (USA) and Auckland (new Zealand).<br />
In the Analgesics category, <strong>Bayer</strong> Aspirin has been<br />
a leader in pain relief for over 110 years. The new <strong>Bayer</strong><br />
Advanced Aspirin represents the most exciting Aspirin<br />
innovation to date in the United States. Launched by the<br />
Consumer Care Division in 2011, the product was the<br />
result of more than five years of research and development<br />
and uses breakthrough patented technology to<br />
reduce the Aspirin particles into micro-particles. This<br />
next generation of Aspirin targets younger, more active<br />
consumers.<br />
Aflibercept Prevention of abnormal retinal angiogenesis following<br />
pathological myopia<br />
BAY 86-6150 (rFVIIa mutein) Treatment of hemophilia A (Phase II/III)<br />
BAY 94-9027 (rFVIII mutein) Treatment of hemophilia A<br />
Ciprofloxacin Inhale Treatment of pulmonary infections<br />
LCS-16 (ULD LnG Contraceptive System) Intrauterine contraception, duration of use: up to 5 years<br />
Prasterone ** Treatment of vulvovaginal atrophy<br />
Rivaroxaban Prevention of major adverse cardiac events (MACE)<br />
Sodium deoxycholate *** Injection for reduction of submental fat<br />
Sorafenib Treatment of breast cancer<br />
Sorafenib Treatment of liver cancer, adjuvant therapy<br />
Sorafenib Treatment of kidney cancer, adjuvant therapy<br />
Sorafenib Treatment of thyroid cancer<br />
Tedizolid Treatment of complicated skin and lung infections<br />
rESEArCH AnD DEvEloPMEnT<br />
* as of February 11, 2013<br />
** prasterone = vaginorm<br />
*** sodium deoxycholate =<br />
ATX-101<br />
The nature of drug discovery and<br />
development is such that not all<br />
compounds can be expected to<br />
meet the predefined project<br />
goals. It is possible that any or all<br />
of the projects listed above may<br />
have to be discontinued due to<br />
scientific and / or commercial<br />
reasons and will not result in<br />
commercialized products. It is also<br />
possible that the requisite Food<br />
and Drug Administration (FDA),<br />
European Medicines Agency<br />
(EMA) or other regulatory<br />
approvals will not be granted for<br />
these compounds.<br />
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