Myelodysplastic Syndromes

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WHO MDS Classification • Refractory cytopenia with multilineage dysplasia – Dysplasia in >10% of cells in 2 lineages – Blasts
The patient is a 32 year old taxi driver who presents with a 4 month history of increasing fatigue. He is transferred with a presumed diagnosis of MDS or acute leukemia. CBC shows: WBC 3.6 x10 9 /L; neuts 1.6 x10 9 /L Hgb 6.1 g/dL Hct 17.3% MCV 102 fl Platelets 190 x10 9 /L Megaloblastic anemia (associated with vitamin B12 or folate def) • peripheral blood smear: – macro-ovalocytes – hypersegmented neutrophils • Bone marrow: – Megaloblastic change in erythroid, and granulocytic precursors – Erythroid hyperplasia and left shift – Mild dyserythropoiesis – With or without mild megakaryocytic dysplasia In this patient reticulocytes and nrbc were seen on the blood smear 4 days following vitamin B12 replacement 13
Page 1 and 2: Myelodysplastic Syndromes Joan E. E
Page 3 and 4: WHO MDS Classification • Dysplasi
Page 5 and 6: Neutrophil dysplasia • Hypo-, agr
Page 7 and 8: MDS cytogenetics Presumptive diagno
Page 9 and 10: Hypocellular MDS • Proper classif
Page 11: Paryoxysmal Nocturnal Hemoglobinuri
Page 15: The patient is a 56 year old man wh

Myelodysplastic Syndromes

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