Docteur de l'université Automatic Segmentation and Shape Analysis ...

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14 Chapter 1 Introduction Figure 1.6: Coronal section of Alzheimer’s brain with mild ventricular dilatation, and hippocampal atrophy (arrow). Image modified from Barkhof et al. (2011). down in moderate AD (Frisoni et al., 2009). The structural markers are more sensitive to the change from MCI to dementia in AD. 1.2 Plan of the thesis In the following chapters, this thesis will discuss the topics on MR image segmentation, shape modeling of biological objects, the shape analysis of hippocampus, and the detection of the hippocampal shape changes in AD. In Chapter 2, the relevant literature on the segmentation of hippocampus, espe- cially the development of atlas-based methods, the statistical modeling of shapes,
Chapter 1 Introduction 15 and the statistical analysis of hippocampal volume and shape in AD studies are reviewed. In Chapter 3, we will introduce the hippocampal segmentation method on MR images using multiple atlases. A supervised method to build a population specific atlas set is developed. The issue of atlas selection in multi-atlas based segmentation is discussed. Two alternative criteria for atlas selection are proposed and evaluated. In Chapter 4, we detailed the construction of the statistical shape models (SSMs) for hippocampus and the establishment of correspondence by groupwise optimiza- tion. We also developed the extrapolation of the SSM to the unseen point set and the shape parameter estimation based on expectation-maximization algorithm. In Chapter 5, we used the SSMs to perform the shape analysis on the hippocampus and to detect the hippocampal shape changes in AD. We used statistical test to select hippocampal landmarks exhibiting significant difference between the control and the AD groups. We then developed shape analysis method to model the shape variability on the subregions identified by the statistical tests, in order to improve the discrimination ability of the shape analysis using SSM, and correlation of the hippocampal shape description with decline of episodic memory in AD. The thesis concludes in Chapter 6, which summarizes the work presented in the preparation of this thesis, and outlines the possible future works.
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144 LIST OF PUBLICATIONS using dive
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146 BIBLIOGRAPHY Alzheimer, A. (191
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148 BIBLIOGRAPHY Baillard, C., Hell
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150 BIBLIOGRAPHY of post mortem mag
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152 BIBLIOGRAPHY B. (2008). Three-d
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154 BIBLIOGRAPHY Cootes, T. F., Tay
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156 BIBLIOGRAPHY head in MR images
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158 BIBLIOGRAPHY Evans, A. C., Coll
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BIBLIOGRAPHY 161 Ghanei, A., Soltan
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BIBLIOGRAPHY 163 Heckemann, R. A.,
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BIBLIOGRAPHY 165 R. C. (2003). MRI
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BIBLIOGRAPHY 167 Konrad, C., Ukas,
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BIBLIOGRAPHY 169 Mahony, R. and Man
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BIBLIOGRAPHY 171 disease, mild cogn
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BIBLIOGRAPHY 173 Petersen, R. C., S
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BIBLIOGRAPHY 175 Rorden, C. and Bre
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BIBLIOGRAPHY 177 Shen, K., Bourgeat
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BIBLIOGRAPHY 179 Barillot, C., Hayn
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BIBLIOGRAPHY 181 Tzourio-Mazoyer, N
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BIBLIOGRAPHY 183 Vos, F. M., de Bru
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BIBLIOGRAPHY 185 Woolrich, M. W., J
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