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134 Chapter 5 Quantitative shape analysis of hippocampus in AD (a) Left hippocampus (b) Right hippocampus . . .0 .1.0 .2.0 Figure 5.14: The variation along the direction of mean difference ¯ XNC − ¯ XAD between the normal control (NC) group and the Alzheimer’s disease (AD) group, color-coded map showing the magnitude of variation on the rigidly aligned model (MR). From left to right: superior, medial, inferior, lateral. to the changes induced by the disease. By applying a statistical test on the land- mark points in the SSM, we can identify the regions on the hippocampal surface which display more significant effect of the disease on the morphology and thus are more discriminative between AD and NC groups. The PCA performed on this subset produced variation modes which were used as features for the classification between these two groups. The principal variation modes on these regions were more sensitive to the shape change from NC to AD, and better correlated with the measurements of memory decline.
Chapter 5 Quantitative shape analysis of hippocampus in AD 135 (a) Left hippocampus (b) Right hippocampus . . .0 .1.0 .2.0 Figure 5.15: The variation along the direction of mean difference ¯ XNC − ¯ XAD between the normal control (NC) group and the Alzheimer’s disease (AD) group, color-coded map showing the magnitude of variation on the similarity aligned model (MS). From left to right: superior, medial, inferior, lateral.
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UNIVERSITE DE BOURGOGNE U.F.R. SCIE
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Résumé L’objectif de cette thè
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Abstract The aim of this thesis is
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TABLE DES MATIÈRES Acknowledgement
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TABLE DES MATIÈRES xi 4.1.4.3 Spec
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LISTE DES FIGURES 1.1 Cortical atro
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LISTE DES FIGURES xvii 5.6 The accu
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2 Chapter 1 Introduction The resear
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4 Chapter 1 Introduction .β.α .γ
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6 Chapter 1 Introduction 1.1.2 Hipp
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44 Chapter 3 Hippocampal segmentati
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Page 162 and 163: 144 LIST OF PUBLICATIONS using dive
Page 164 and 165: 146 BIBLIOGRAPHY Alzheimer, A. (191
Page 166 and 167: 148 BIBLIOGRAPHY Baillard, C., Hell
Page 168 and 169: 150 BIBLIOGRAPHY of post mortem mag
Page 170 and 171: 152 BIBLIOGRAPHY B. (2008). Three-d
Page 172 and 173: 154 BIBLIOGRAPHY Cootes, T. F., Tay
Page 174 and 175: 156 BIBLIOGRAPHY head in MR images
Page 176 and 177: 158 BIBLIOGRAPHY Evans, A. C., Coll
Page 179 and 180: BIBLIOGRAPHY 161 Ghanei, A., Soltan
Page 181 and 182: BIBLIOGRAPHY 163 Heckemann, R. A.,
Page 183 and 184: BIBLIOGRAPHY 165 R. C. (2003). MRI
Page 185 and 186: BIBLIOGRAPHY 167 Konrad, C., Ukas,
Page 187 and 188: BIBLIOGRAPHY 169 Mahony, R. and Man
Page 189 and 190: BIBLIOGRAPHY 171 disease, mild cogn
Page 191 and 192: BIBLIOGRAPHY 173 Petersen, R. C., S
Page 193 and 194: BIBLIOGRAPHY 175 Rorden, C. and Bre
Page 195 and 196: BIBLIOGRAPHY 177 Shen, K., Bourgeat
Page 197 and 198: BIBLIOGRAPHY 179 Barillot, C., Hayn
Page 199 and 200: BIBLIOGRAPHY 181 Tzourio-Mazoyer, N
Page 201 and 202: BIBLIOGRAPHY 183 Vos, F. M., de Bru
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BIBLIOGRAPHY 185 Woolrich, M. W., J
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Docteur de l'université Automatic Segmentation and Shape Analysis ...

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