Docteur de l'université Automatic Segmentation and Shape Analysis ...

LISTE DES FIGURES
1.1 Cortical atrophy in Alzheimer’s brain, as compared with the normal
brain. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
1.2 Generation of amyloid-β from the amyloid precursor protein (APP). 4
1.3 Limbic system. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
1.4 Coronal section of the hippocampal body after intravascular India
ink injection. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
1.5 A theoretical model of natural progression of cognitive and biological
markers of Alzheimer disease and the sensitivity of markers to
disease state. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
1.6 Coronal section of Alzheimer’s brain with mild ventricular dilatation,
and hippocampal atrophy. . . . . . . . . . . . . . . . . . . . . 14
2.1 Samples of Talairach labelings. . . . . . . . . . . . . . . . . . . . . 19
2.2 AAL labeling overlayed on collins27. . . . . . . . . . . . . . . . . . 20
2.3 Delineation of hippocampus in the labelings from the Internet Brain
Segmentation Repository (IBSR). . . . . . . . . . . . . . . . . . . . 21
2.4 Hierarchy of shape spaces. . . . . . . . . . . . . . . . . . . . . . . . 31
2.5 Tracing hippocampal volume. . . . . . . . . . . . . . . . . . . . . . 38
3.1 Diagram demonstrating the process segmentation using multiple
atlases. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46
3.2 Diagram demonstrating the process building a set of population
specific atlases. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
3.3 Least angle regression (LAR) with the first 2 cavariates/altases. . . 59
3.4 Probability images of hippocampus of an NC subject in AIBL data. 61
3.5 Comparison of result hippocampal segmentation of one example
NC case by fusing 31 atlases selected according to different criteria. 65
3.6 The average Dice similarity coefficient (DSC) of left and right hippocampi
using locally weighted voting (LWV) on the normal control
(NC) atlas set with varying power of the MSD function in the atlas
weight. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
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