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120 Chapter 5 Quantitative shape analysis of hippocampus in AD Table 5.1: Demographic information of subjects used in the study. Diagnosis Number (M/F) Age Yeas of education Training set Testing set Total NC 34/26 77.0(4.8) 16.3(2.7) AD 31/29 75.2(6.7) 14.7(3.0) NC 35/43 76.3(5.2) 15.4(3.1) AD 20/19 77.8(7.3) 14.4(3.7) NC 69/69 76.6(5.0) 15.8(2.9) AD 51/48 76.2(7.0) 14.6(3.3) hippocampal shapes in different ways. The combinations of alignment in the SSMs are listed in Table 5.2. Table 5.2: Choices of alignment in SSMs Procrustes alignment II in shape modeling MR MS Procrustes alignment I LR 1 2 in localization LS 3 4 1. In the localization step, the significance maps are produced from rigidly aligned size-and-shape set LR, and in the shape modeling step the subregional SSM is built on rigidly aligned the size-and-shape set MR; 2. in the localization step, the significance maps are produced from rigidly aligned size-and-shape set LR, and in the shape modeling step the subregional SSM is built on similarity aligned the shape set MS; 3. in the localization step, the significance maps are produced from similarity aligned shape set LS, and in the shape modeling step the subregional SSM is built on rigidly aligned the size-and-shape set MR; 4. in the localization step, the significance maps are produced from similarity aligned shape set LS, and in the shape modeling step the subregional SSM is built on similarity aligned the shape set MS. In the experiments, the hippocampi on both the right and the left hand sides of 60 NC and 60 AD subjects from ADNI data were used as a training set to build the SSM. Hotelling’s T 2 test was performed on each SSM between the AD and NC groups, with the resulting significance maps shown in Figure 5.2. The results after the thresholding are shown in Figure 5.3.
Chapter 5 Quantitative shape analysis of hippocampus in AD 121 (a) Rigid (b) Similarity . . .0 .p > 0.05 Figure 5.2: The significance map of local difference on hippocampal surface by Hotelling’s T 2 test. For each landmark in the training set, a Hotelling’s T 2 test is carried out between the normal control (NC) group, and the Alzheimer’s disease (AD) group, resulting the map of p-values. Top: superior view; bottom: inferior view. We vary the thresholds of the significance level when selecting the landmarks at α = 0.0001, 0.0002, · · · ,0.0009, 0.001, 0.002, · · · ,0.009, 0.01, 0.02, · · · ,0.09, 0.1, 0.2, · · · ,0.9. The number of landmarks thresholded at each significance level is plotted in Figure 5.4. For the purpose of comparison, conventional PCA on all the landmarks was also performed, using models MR and MS. 5.5.3 Disease classification of AD using regional SSM The first 15 principal components in each of the SSM were used as features for classification, which accounted for approximately 90% of the total variance in the training set (Heimann and Meinzer, 2009). The rest of the modes individually
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UNIVERSITE DE BOURGOGNE U.F.R. SCIE
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Résumé L’objectif de cette thè
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Abstract The aim of this thesis is
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TABLE DES MATIÈRES Acknowledgement
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Page 164 and 165: 146 BIBLIOGRAPHY Alzheimer, A. (191
Page 166 and 167: 148 BIBLIOGRAPHY Baillard, C., Hell
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Page 170 and 171: 152 BIBLIOGRAPHY B. (2008). Three-d
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Page 183 and 184: BIBLIOGRAPHY 165 R. C. (2003). MRI
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BIBLIOGRAPHY 177 Shen, K., Bourgeat
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BIBLIOGRAPHY 179 Barillot, C., Hayn
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BIBLIOGRAPHY 181 Tzourio-Mazoyer, N
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BIBLIOGRAPHY 183 Vos, F. M., de Bru
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BIBLIOGRAPHY 185 Woolrich, M. W., J
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