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Docteur de l'université Automatic Segmentation and Shape Analysis ...

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Chapter 4 Statistical shape mo<strong>de</strong>l of Hippocampus 93<br />

gives the conditional expectation<br />

E(Ast|T ) = πst · p(T (¯p s X)|pk Y )<br />

∑<br />

l πsl · p(T (¯p s X)|pl Y )<br />

(4.58)<br />

Viewing the correspon<strong>de</strong>nce matching matrix A as hid<strong>de</strong>n variable, EM algorithm<br />

can be used to minimize the free energy<br />

F (A, T ) = −EA(log p(T (¯x), A|y)) + EA(log p(A)). (4.59)<br />

In implementation, isotropic Gaussian noise with covariance σ 2 I is assumed<br />

p(p ′ |p) =<br />

1<br />

(2π) 3 exp<br />

2 σ3 (<br />

− 1<br />

2σ2 p − p′ 2<br />

)<br />

(4.60)<br />

where p − p ′ is the Eucli<strong>de</strong>an distance between the point p <strong>and</strong> p ′ . The prior<br />

distribution is set to be uniform<br />

πst = 1<br />

kY<br />

, ∀s, t. (4.61)<br />

The EM algorithm estimates the latent match A <strong>and</strong> the transformation T alterna-<br />

tively. In the Expectation-step (E-step), the algorithm estimates the expectation<br />

of the match matrix A based on the current estimate of T<br />

A ∗ st = E(Ast|T ) = e−T (¯ps X )−pt Y 2 /2σ2 ∑<br />

l e−T (¯ps X )−pl Y 2 , (4.62)<br />

/2σ2 In the Maximization-step (M-step), the transformation T is estimated by mini-<br />

mizing the energy<br />

T ∗ = arg min<br />

T<br />

1<br />

kσ2 ∑<br />

s,t<br />

A ∗ <br />

<br />

st<br />

T (¯p s X) − p t <br />

<br />

Y<br />

2<br />

, (4.63)<br />

where the transformation T = (TA, b) is composed of an affine transformation TA,<br />

<strong>and</strong> the <strong>de</strong>formation of the SSM along the vector b (eq. 4.51)<br />

T ( ¯ X) = TA( ¯ X + Wb) <strong>and</strong> T (¯p s X) = TA (¯p s X + (Wb) s ) , (4.64)

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