A systematic review of the effectiveness of adalimumab

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Additional ongoing/unpublished trials Source: ClinicalTrials.gov http://www.clinicaltrials.gov/ct http://www.clinicaltrials.gov/ct/show/NCT00034060 ?order=1 The role of cytokines on growth hormone suppression in premenopausal women with rheumatoid arthritis and the effect of treatment with etanercept. Sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Diseases http://www.clinicaltrials.gov/ct/show/NCT00099554 ?order=2 Effectiveness and safety of Enbrel ® (etanercept) in rheumatoid arthritis subjects who have failed Remicade ® (infliximab). Sponsored by Abbott Laboratories http://www.clinicaltrials.gov/ct/show/NCT00095147 ?order=4 Abatacept and infliximab in combination with methotrexate in subjects with rheumatoid arthritis. Sponsored by Bristol-Myers Squibb Appendix 11 Ongoing research © Queen’s Printer and Controller of HMSO 2006. All rights reserved. Health Technology Assessment 2006; Vol. 10: No. 42 http://www.clinicaltrials.gov/ct/show/NCT00056602 ?order=5 Clinically important changes in rheumatoid arthritis. Sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Diseases Source: Controlled-Trials.com http://www.controlled-trials.com/ http://www.controlledtrials.com/mrct/trial/INFLIXIMAB%7CADALIMU MAB%7CETANERCEPT% 7CRHEUMATOID%20ARTHRITIS/1059/67577.h tml Preference of rheumatoid arthritis (RA) patients of Enbrel ® (etanercept) auto-injector versus Enbrel ® pre-filled syringes. Sponsored by Amgen http://www.controlledtrials.com/mrct/trial/INFLIXIMAB%7CADALIMU MAB%7CETANERCEPT% 7CRHEUMATOID%20ARTHRITIS/1059/67629.h tml OPPOSITE: Open-label, Pilot Protocol of Patients with Rheumatoid Arthritis who Switch to Infliximab after an Incomplete Response To Etanercept. Sponsored by Centocor 229
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A systematic review of the effectiv
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A systematic review of the effectiv
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Objectives: This report reviews the
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Glossary and list of abbreviations
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viii Glossary and list of abbreviat
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Background Rheumatoid arthritis (RA
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increased risk of serious infection
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Summary RA is a common, chronic, in
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(IL-2) and interleukin-6 (IL-6), pr
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Assessment of response to DMARDs Re
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combination with methotrexate or al
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disease between clinic appointments
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14 Effectiveness in juvenile arthri
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16 Effectiveness adalimumab plus me
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18 Effectiveness Monoclonal Antibod
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20 TABLE 1 Description of included
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22 TABLE 2 Quality of included RCTs
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24 Effectiveness change in modified
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26 Effectiveness TABLE 4 Meta-analy
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28 Effectiveness Review: Adalimumab
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30 Effectiveness Review: Adalimumab
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32 TABLE 6 Effectiveness Descriptio
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34 TABLE 6 Effectiveness Descriptio
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36 TABLE 7 Effectiveness Quality of
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38 Effectiveness etanercept trials.
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40 Effectiveness TABLE 9 Summary of
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42 Effectiveness Review: Etanercept
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54 Effectiveness TABLE 11 Summary o
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56 TABLE 12 Description of included
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58 TABLE 13 Quality of included RCT
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60 Effectiveness per week and escal
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62 Effectiveness significant advant
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64 Effectiveness Review: Infliximab
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66 Effectiveness Review: Infliximab
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68 Effectiveness FIGURE 44 Malignan
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70 TABLE 17 Effectiveness Summary o
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Summary of review of existing econo
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TABLE 20 Summary of published ICERs
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TABLE 21 Published etanercept econo
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TABLE 23 Published economic analyse
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TABLE 25 Treatment sequences: adali
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management of RA, i.e. 1st and 2nd
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To estimate the long-term consequen
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TABLE 32 TNF inhibitors as last act
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TABLE 34 Basic structure of the mod
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een quit on grounds of toxicity, ad
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TABLE 39 Strategy set: adalimumab a
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TABLE 43 Beta distributions for HAQ
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TABLE 44 Early cessation of DMARDs:
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TABLE 46 Unit costs for tests and v
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following properties, according to
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TABLE 52 Base case: TNF inhibitors
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TABLE 54 Base case: TNF inhibitors
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TABLE 59 Third TNF inhibitor follow
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TABLE 65 Sensitivity analyses: TNF
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TABLE 67 Sensitivity analyses: TNF
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The substantial economic impact of
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Summary Effectiveness: principal fi
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inhibitors, although the incrementa
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introduce bias which generally exag
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Adalimumab, etanercept and inflixim
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1. Jobanputra P, Barton P, Bryan S,
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46. Young A, Dixey J, Cox N, Davies
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tumor necrosis factor therapy in th
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arthritis: a 12-week, double-blind,
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171. Geborek P, Crnkic M, Petersson
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216. Schotte H, Willeke P, Mickholz
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The Health Assessment Questionnaire
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Cochrane Library (CENTRAL) 2005 Iss
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Appendix 3 © Queen’s Printer and
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TABLE 69 Studies excluded from clin
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148 Appendix 4 TABLE 71 Meta-analys
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150 Appendix 4 TABLE 73 Meta-analys
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152 Appendix 4 Infliximab versus pl
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154 Appendix 4 Infliximab plus MTX
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Ovid MEDLINE(R) 1966 to February we
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Appendix 8 © Queen’s Printer and
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TABLE 79 Wong et al., 2002 161 © Q
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TABLE 80 Kobelt et al., 2003 162 (c
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TABLE 82 Brennan et al., 2004 160
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TABLE 85 Bansback et al., 2005 166
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176 Appendix 9 TABLE 89 Strategy se
Page 195 and 196: Extensive sensitivity analysis was
Page 197 and 198: TABLE 96 Variation 1: TNF inhibitor
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Page 201 and 202: TABLE 102 Variation 3: TNF inhibito
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Page 243: TABLE 165 Variation 18: TNF inhibit
Page 248 and 249: 232 Health Technology Assessment re
Page 261 and 262: Members Chair, Professor Tom Walley
Page 263 and 264: Members Chair, Professor Bruce Camp
Page 266: Feedback The HTA Programme and the
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A systematic review of the effectiveness of adalimumab

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