A systematic review of the effectiveness of adalimumab

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176 Appendix 9 TABLE 89 Strategy set: adalimumab and infliximab possibly followed by etanercept Moves dependent on toxicity Treatment Always move to Relevant toxicity If toxic, move to Otherwise, move to MTX MTX SSZ MTX+SSZ SSZ Adal MTX+SSZ Adal Adal Infl+MTX Infl+MTX Divergence point Option 1 Etan Etan LEF Option 2 LEF LEF GST GST AZA AZA CyA CyA CyA or MTX DPen CyA+MTX CyA+MTX DPen DPen Pall TABLE 90 Strategy set: etanercept and adalimumab possibly followed by infliximab Moves dependent on toxicity Treatment Always move to Relevant toxicity If toxic, move to Otherwise, move to MTX MTX SSZ MTX+SSZ SSZ Etan MTX+SSZ Etan Etan Adal Adal Divergence point Option 1 Infl+MTX Infl+MTX LEF Option 2 LEF LEF GST GST AZA AZA CyA CyA CyA or MTX DPen CyA+MTX CyA+MTX DPen DPen Pall TABLE 91 Strategy set: etanercept and infliximab possibly followed by adalimumab Moves dependent on toxicity Treatment Always move to Relevant toxicity If toxic, move to Otherwise, move to MTX MTX SSZ MTX+SSZ SSZ Etan MTX+SSZ Etan Etan Infl+MTX Infl+MTX Divergence point Option 1 Adal Adal LEF Option 2 LEF LEF GST GST AZA AZA CyA CyA CyA or MTX DPen CyA+MTX CyA+MTX DPen DPen Pall
TABLE 92 Strategy set: infliximab and adalimumab possibly followed by etanercept © Queen’s Printer and Controller of HMSO 2006. All rights reserved. Health Technology Assessment 2006; Vol. 10: No. 42 Moves dependent on toxicity Treatment Always move to Relevant toxicity If toxic, move to Otherwise, move to MTX MTX SSZ MTX+SSZ SSZ Infl+MTX MTX+SSZ Infl+MTX Infl+MTX Adal Adal Divergence point Option 1 Etan Etan LEF Option 2 LEF LEF GST GST AZA AZA CyA CyA CyA or MTX DPen CyA+MTX CyA+MTX DPen DPen Pall TABLE 93 Strategy set: infliximab and etanercept possibly followed by adalimumab Moves dependent on toxicity Treatment Always move to Relevant toxicity If toxic, move to Otherwise, move to MTX MTX SSZ MTX+SSZ SSZ Infl+MTX MTX+SSZ Infl+MTX Infl+MTX Etan Etan Divergence point Option 1 Adal Adal LEF Option 2 LEF LEF GST GST AZA AZA CyA CyA CyA or MTX DPen CyA+MTX CyA+MTX DPen DPen Pall 177
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A systematic review of the effectiv
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A systematic review of the effectiv
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Objectives: This report reviews the
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Glossary and list of abbreviations
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viii Glossary and list of abbreviat
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Background Rheumatoid arthritis (RA
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increased risk of serious infection
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Summary RA is a common, chronic, in
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(IL-2) and interleukin-6 (IL-6), pr
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Assessment of response to DMARDs Re
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combination with methotrexate or al
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disease between clinic appointments
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14 Effectiveness in juvenile arthri
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16 Effectiveness adalimumab plus me
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18 Effectiveness Monoclonal Antibod
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20 TABLE 1 Description of included
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22 TABLE 2 Quality of included RCTs
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24 Effectiveness change in modified
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26 Effectiveness TABLE 4 Meta-analy
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28 Effectiveness Review: Adalimumab
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30 Effectiveness Review: Adalimumab
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32 TABLE 6 Effectiveness Descriptio
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34 TABLE 6 Effectiveness Descriptio
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36 TABLE 7 Effectiveness Quality of
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38 Effectiveness etanercept trials.
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40 Effectiveness TABLE 9 Summary of
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42 Effectiveness Review: Etanercept
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54 Effectiveness TABLE 11 Summary o
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56 TABLE 12 Description of included
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58 TABLE 13 Quality of included RCT
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60 Effectiveness per week and escal
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62 Effectiveness significant advant
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64 Effectiveness Review: Infliximab
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66 Effectiveness Review: Infliximab
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68 Effectiveness FIGURE 44 Malignan
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70 TABLE 17 Effectiveness Summary o
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Summary of review of existing econo
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TABLE 20 Summary of published ICERs
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TABLE 21 Published etanercept econo
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TABLE 23 Published economic analyse
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TABLE 25 Treatment sequences: adali
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management of RA, i.e. 1st and 2nd
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To estimate the long-term consequen
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TABLE 32 TNF inhibitors as last act
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TABLE 34 Basic structure of the mod
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een quit on grounds of toxicity, ad
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TABLE 39 Strategy set: adalimumab a
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TABLE 43 Beta distributions for HAQ
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TABLE 44 Early cessation of DMARDs:
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TABLE 46 Unit costs for tests and v
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following properties, according to
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TABLE 52 Base case: TNF inhibitors
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TABLE 54 Base case: TNF inhibitors
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TABLE 59 Third TNF inhibitor follow
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TABLE 65 Sensitivity analyses: TNF
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TABLE 67 Sensitivity analyses: TNF
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The substantial economic impact of
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Summary Effectiveness: principal fi
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inhibitors, although the incrementa
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introduce bias which generally exag
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Adalimumab, etanercept and inflixim
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Page 145 and 146: 46. Young A, Dixey J, Cox N, Davies
Page 147 and 148: tumor necrosis factor therapy in th
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Page 151 and 152: 171. Geborek P, Crnkic M, Petersson
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Page 155 and 156: The Health Assessment Questionnaire
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Page 159 and 160: Appendix 3 © Queen’s Printer and
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Page 164 and 165: 148 Appendix 4 TABLE 71 Meta-analys
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Page 168 and 169: 152 Appendix 4 Infliximab versus pl
Page 170 and 171: 154 Appendix 4 Infliximab plus MTX
Page 173: Ovid MEDLINE(R) 1966 to February we
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Page 179 and 180: TABLE 79 Wong et al., 2002 161 © Q
Page 181 and 182: TABLE 80 Kobelt et al., 2003 162 (c
Page 183 and 184: TABLE 82 Brennan et al., 2004 160
Page 185 and 186: TABLE 83 Kobelt et al., 2004 163 (c
Page 187 and 188: TABLE 85 Bansback et al., 2005 166
Page 189: TABLE 86 Kobelt et al., 2005 167 (c
Page 195 and 196: Extensive sensitivity analysis was
Page 197 and 198: TABLE 96 Variation 1: TNF inhibitor
Page 199 and 200: TABLE 99 Variation 2: TNF inhibitor
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Page 221 and 222: TABLE 132 Variation 10: TNF inhibit
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TABLE 165 Variation 18: TNF inhibit
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Volume 1, 1997 No. 1 Home parentera
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No. 3 Screening for sickle cell dis
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No. 25 A rapid and systematic revie
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No. 11 First and second trimester a
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No. 23 Clinical effectiveness and c
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No. 28 Outcomes of electrically sti
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No. 28 Adefovir dipivoxil and pegyl
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246 Health Technology Assessment Pr
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248 Health Technology Assessment Pr
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A systematic review of the effectiveness of adalimumab

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