A systematic review of the effectiveness of adalimumab
A systematic review of the effectiveness of adalimumab A systematic review of the effectiveness of adalimumab
106 Health economics TABLE 56 Second TNF inhibitor following adalimumab (40,000 patients) Option Cost (£) QSE QALYs QSE Etan 58,871 184 5.7622 0.0235 Infl 46,036 146 5.0558 0.0224 Base 15,972 36 4.9302 0.0206 Comparison Diff. cost (£) QSE Diff. QALY QSE Etan – Base 42,899 179 0.8320 0.0231 Infl – Base 30,064 142 0.1256 0.0220 Etan – Infl 12,835 216 0.7064 0.0234 Comparison ICER (£ per QALY) Quasi-CI Etan – Base 51,600 48,800 to 54,600 Infl – Base 239,000 177,000 to 368,000 Etan – Infl 18,200 16,900 to 19,600 TABLE 57 Second TNF inhibitor following etanercept (100,000 patients) Option Cost (£) QSE QALYs QSE Adal 45,666 95 4.8230 0.0138 Infl 45,424 91 4.8559 0.0139 Base 15,653 23 4.6988 0.0129 Comparison Diff. cost (£) QSE Diff. QALY QSE Adal – Base 30,013 93 0.1242 0.0136 Infl – Base 29,773 89 0.1571 0.0137 Adal – Infl 240 122 –0.0329 0.0138 Comparison ICER (£ per QALY) Quasi-CI Adal – Base 242,000 198,000 to 310,000 Infl – Base 190,000 161,000 to 230,000 Adal – Infl Infl more effective than Adal; diff. cost not significant TABLE 58 Second TNF inhibitor following infliximab (40,000 patients) Option Cost (£) QSE QALYs QSE Adal 46,365 152 5.1019 0.0223 Etan 58,844 185 5.7985 0.0237 Base 15,994 36 4.8872 0.0206 Comparison Diff. cost (£) QSE Diff. QALY QSE Adal – Base 30,371 148 0.2147 0.026 Etan – Base 42,850 179 0.9113 0.0232 Etan – Adal 12,479 221 0.6966 0.0234 Comparison ICER (£ per QALY) Quasi-CI Adal – Base 141,000 118,000 to 177,000 Etan – Base 47,000 44,700 to 49,600 Etan – Adal 17,900 16,700 to 19,400
TABLE 59 Third TNF inhibitor following adalimumab and etanercept (100,000 patients) © Queen’s Printer and Controller of HMSO 2006. All rights reserved. Health Technology Assessment 2006; Vol. 10: No. 42 Option Cost (£) QSE QALYs QSE Infl 44,122 90 4.3990 0.0133 Base 15,134 23 4.3289 0.0123 Comparison Diff. cost (£) QSE Diff. QALY QSE Infl – Base 28,988 87 0.0701 0.0133 Comparison ICER (£ per QALY) Quasi-CI Infl – Base 414,000 300,000 to 667,000 TABLE 60 Third TNF inhibitor following adalimumab and infliximab (20,000 patients) Option Cost (£) QSE QALYs QSE Etan 56,640 256 5.2256 0.0318 Base 1,391 50 4.4743 0.0279 Comparison Diff. cost (£) QSE Diff. QALY QSE Etan – Base 41,250 248 0.7513 0.0319 Comparison ICER (£ per QALY) Quasi-CI Etan – Base 54,900 50,600 to 60,100 TABLE 61 Third TNF inhibitor following etanercept and adalimumab (100,000 patients) Option Cost (£) QSE QALYs QSE Infl 44,299 90 4.4228 0.0133 Base 15,130 23 4.3222 0.0123 Comparison Diff. cost (£) QSE Diff. QALY QSE Infl – Base 29169 88 0.1006 0.0134 Comparison ICER (£ per QALY) Quasi-CI Infl – Base 290,000 229,000 to 395,000 TABLE 62 Third TNF inhibitor following etanercept and infliximab (100,000 patients) Option Cost (£) QSE QALYs QSE Adal 44,497 94 4.3904 0.0131 Base 15,130 23 4.3231 0.0123 Comparison Diff. cost (£) QSE Diff. QALY QSE Adal – Base 29,367 92 0.0673 0.0132 Comparison ICER (£ per QALY) Quasi-CI Adal – Base 437,000 313,000 to 720,000 107
- Page 72 and 73: 56 TABLE 12 Description of included
- Page 74 and 75: 58 TABLE 13 Quality of included RCT
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- Page 82 and 83: 66 Effectiveness Review: Infliximab
- Page 84 and 85: 68 Effectiveness FIGURE 44 Malignan
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106<br />
Health economics<br />
TABLE 56 Second TNF inhibitor following <strong>adalimumab</strong> (40,000 patients)<br />
Option Cost (£) QSE QALYs QSE<br />
Etan 58,871 184 5.7622 0.0235<br />
Infl 46,036 146 5.0558 0.0224<br />
Base 15,972 36 4.9302 0.0206<br />
Comparison Diff. cost (£) QSE Diff. QALY QSE<br />
Etan – Base 42,899 179 0.8320 0.0231<br />
Infl – Base 30,064 142 0.1256 0.0220<br />
Etan – Infl 12,835 216 0.7064 0.0234<br />
Comparison ICER (£ per QALY) Quasi-CI<br />
Etan – Base 51,600 48,800 to 54,600<br />
Infl – Base 239,000 177,000 to 368,000<br />
Etan – Infl 18,200 16,900 to 19,600<br />
TABLE 57 Second TNF inhibitor following etanercept (100,000 patients)<br />
Option Cost (£) QSE QALYs QSE<br />
Adal 45,666 95 4.8230 0.0138<br />
Infl 45,424 91 4.8559 0.0139<br />
Base 15,653 23 4.6988 0.0129<br />
Comparison Diff. cost (£) QSE Diff. QALY QSE<br />
Adal – Base 30,013 93 0.1242 0.0136<br />
Infl – Base 29,773 89 0.1571 0.0137<br />
Adal – Infl 240 122 –0.0329 0.0138<br />
Comparison ICER (£ per QALY) Quasi-CI<br />
Adal – Base 242,000 198,000 to 310,000<br />
Infl – Base 190,000 161,000 to 230,000<br />
Adal – Infl Infl more effective than Adal; diff. cost not significant<br />
TABLE 58 Second TNF inhibitor following infliximab (40,000 patients)<br />
Option Cost (£) QSE QALYs QSE<br />
Adal 46,365 152 5.1019 0.0223<br />
Etan 58,844 185 5.7985 0.0237<br />
Base 15,994 36 4.8872 0.0206<br />
Comparison Diff. cost (£) QSE Diff. QALY QSE<br />
Adal – Base 30,371 148 0.2147 0.026<br />
Etan – Base 42,850 179 0.9113 0.0232<br />
Etan – Adal 12,479 221 0.6966 0.0234<br />
Comparison ICER (£ per QALY) Quasi-CI<br />
Adal – Base 141,000 118,000 to 177,000<br />
Etan – Base 47,000 44,700 to 49,600<br />
Etan – Adal 17,900 16,700 to 19,400