Report in English with a Dutch summary (KCE reports 45A)

76 Screening for Colorectal Cancer KCE reports vol.45
Study 1. Nottingham 348, 363 2. Funen 350, 351, 208 3. Göteborg 359-362 4. Minnesota 354, 357, 358 5. Burgundy 364, 207 Towler B. &
Cochrane
CDSR 24
Screening period 1981 1995 1985 (continuing)
Number of
screening rounds
1982 1983 1 st round
1984 1985 2 nd round
1976 1982 (phase 1)
1986 1992 (phase 2)
1988 1998 -
3 6 rounds 9 rounds (aug. 2002) 2 rounds 11 rounds 6 rounds 6 rounds -
Frequency Biennial Biennial
FOBT test
Dietary
restrictions
Total personyears
of
observation,
screening group
Total personyears
of
observation,
control group
Follow-up, median
(years)
Follow-up, range
(years)
Lost to
recruitment (%)
Hemoccult II
unrehydrated
Hemoccult II
unrehydrated
2nd screening after 16-22
months
Hemoccult II
51% rehydrated 1st round
100% rehydrated 2nd round
Annual Biennial Biennial -
Hemoccult II
82.5% rehydrated
Hemoccult II
unrehydrated
No Yes Yes Yes No
844.419 431.190 - 240.325 240.163 476.911 -
843.463 430.755 - 237.420 477.773 -
Most
Hemoccult II
rehydrated
11,7 8,3 -
17
13 11
8,4 18,4
-
-
2.599 / 152.850
1,7% of recruitment 24
Compliance 60% 1 st round 67% 1 st round
Reported
positivity rate
FOBT
2,1%, first round
1,54% all rounds
< 6 persons 24 < 100 persons 24
66% 1 st round
58% 2 nd round
1,0% unrehydrated: 1,9%
rehydrated: 5,8%
11,2% screening 357
11,5% control 357
90% at least 1 round
unrehydrated: 2,4%
rehydrated: 9,8%
10,9% screening 357
11,5% control 357
? ("5,6% of population")
69,5% at least 1 screening
round
38,1% 5 to 6 screening
rounds
unrehydrated: 2,1%
initially
1,4% on average in the 5
successive rounds
67%