Report in English with a Dutch summary (KCE reports 45A)
Report in English with a Dutch summary (KCE reports 45A) Report in English with a Dutch summary (KCE reports 45A)
26 Screening for Colorectal Cancer KCE reports vol.45 Figure 4: Invasive colorectal primary tumor localisations (n = 7.091, including appendix) in Flanders 2000 2001 (source: Vlaams Agentschap Zorg en Gezondheid 39) 2.4 STAGING The TNM staging system (Tumor, Node, Metastasis) 40, 41 of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (Union Internationale Contre le Cancer - UICC) is now the standard for colorectal cancer staging widely used by national, regional, and local tumor registries in the United States and internationally. In short, it is the international language of colorectal cancer staging in all disciplines. The TNM system has three additional advantages over other staging systems. First, it is data-driven and has a process in place for continuous improvement based on ongoing expert review of existing data. Second, it has a comprehensive set of definitions and rules of application that ensure uniform use. Third, it is multidisciplinary in design and is pertinent to all modern techniques of stage evaluation. Figure 5 shows the distribution of colorectal cancer TNM stages in males and females in Flanders for the years 2000 - 2001. Stage distributions in males and females show a very comparable pattern. These data also show that the stage distribution is very similar in the different age categories (not shown). This staging illustrates the extent of colorectal cancer at the time of diagnosis and enabled the classification of patients into prognostically comparable categories. Although the importance of good staging is well-recognised, these data were not always passed on to the cancer registry. In addition, these data may have been incomplete or missing from the medical files. These are possible reasons why the cancer registry encountered an important percentage of missing data. With the introduction in 2003 of financial reimbursement for multidisciplinary oncological consultations, it might be expected that these data will be more complete in the future because payment is only made if these data are completed.
KCE reports vol.45 Screening for Colorectal Cancer 27 Figure 5: Colorectal cancer stages in 2000 - 2001, TNM 5th edition 1997 (source: Vlaams Agentschap Zorg en Gezondheid 39) The older Dukes staging system 42 for CRC and its later modifications (mainly the Modified Dukes-Astler-Coller staging - MAC 43, 44) is a pathological staging based on resection of the tumor and measures the depth of invasion through the mucosa and bowel wall. It does not take into account the level of nodal involvement or the grade of the tumor. It is, however, still widely used in surgical publications in Belgium and other European countries. Based on different sources 40, 41, 45, 44 we produced a comprehensive overview of the TNM stages for CRC and their correlates with Dukes and MAC classifications (Table 4).
- Page 1 and 2: Health Technology Assessment Colore
- Page 3 and 4: Health Technology Assessment Colore
- Page 5 and 6: KCE reports vol.45A Colorectale Kan
- Page 7 and 8: KCE reports vol.45A Colorectale Kan
- Page 9: KCE reports vol.45A Colorectale Kan
- Page 12 and 13: 2 Screening for Colorectal Cancer K
- Page 14 and 15: 4 Screening for Colorectal Cancer K
- Page 16 and 17: 6 Screening for Colorectal Cancer K
- Page 18 and 19: 8 Screening for Colorectal Cancer K
- Page 20 and 21: 10 Screening for Colorectal Cancer
- Page 22 and 23: 12 Screening for Colorectal Cancer
- Page 24 and 25: 14 Screening for Colorectal Cancer
- Page 26 and 27: 16 Screening for Colorectal Cancer
- Page 28 and 29: 18 Screening for Colorectal Cancer
- Page 30 and 31: 20 Screening for Colorectal Cancer
- Page 32 and 33: 22 Screening for Colorectal Cancer
- Page 34 and 35: 24 Screening for Colorectal Cancer
- Page 38 and 39: 28 Screening for Colorectal Cancer
- Page 40 and 41: 30 Screening for Colorectal Cancer
- Page 42 and 43: 32 Screening for Colorectal Cancer
- Page 44 and 45: 34 Screening for Colorectal Cancer
- Page 46 and 47: 36 Screening for Colorectal Cancer
- Page 48 and 49: 38 Screening for Colorectal Cancer
- Page 50 and 51: 40 Screening for Colorectal Cancer
- Page 52 and 53: 42 Screening for Colorectal Cancer
- Page 54 and 55: 44 Screening for Colorectal Cancer
- Page 56 and 57: 46 Screening for Colorectal Cancer
- Page 58 and 59: 48 Screening for Colorectal Cancer
- Page 60 and 61: 50 Screening for Colorectal Cancer
- Page 62 and 63: 52 Screening for Colorectal Cancer
- Page 64 and 65: 54 Screening for Colorectal Cancer
- Page 66 and 67: 56 Screening for Colorectal Cancer
- Page 68 and 69: 58 Screening for Colorectal Cancer
- Page 70 and 71: 60 Screening for Colorectal Cancer
- Page 72 and 73: 62 Screening for Colorectal Cancer
- Page 74 and 75: 64 Screening for Colorectal Cancer
- Page 76 and 77: 66 Screening for Colorectal Cancer
- Page 78 and 79: 68 Screening for Colorectal Cancer
- Page 80 and 81: 70 Screening for Colorectal Cancer
- Page 82 and 83: 72 Screening for Colorectal Cancer
- Page 84 and 85: 74 Screening for Colorectal Cancer
26 Screen<strong>in</strong>g for Colorectal Cancer <strong>KCE</strong> <strong>reports</strong> vol.45<br />
Figure 4: Invasive colorectal primary tumor localisations (n = 7.091,<br />
<strong>in</strong>clud<strong>in</strong>g appendix) <strong>in</strong> Flanders 2000 2001 (source: Vlaams<br />
Agentschap Zorg en Gezondheid 39)<br />
2.4 STAGING<br />
The TNM stag<strong>in</strong>g system (Tumor, Node, Metastasis) 40, 41 of the American Jo<strong>in</strong>t<br />
Committee on Cancer (AJCC) and the International Union Aga<strong>in</strong>st Cancer<br />
(Union Internationale Contre le Cancer - UICC) is now the standard for<br />
colorectal cancer stag<strong>in</strong>g widely used by national, regional, and local tumor<br />
registries <strong>in</strong> the United States and <strong>in</strong>ternationally. In short, it is the <strong>in</strong>ternational<br />
language of colorectal cancer stag<strong>in</strong>g <strong>in</strong> all discipl<strong>in</strong>es. The TNM system has<br />
three additional advantages over other stag<strong>in</strong>g systems. First, it is data-driven<br />
and has a process <strong>in</strong> place for cont<strong>in</strong>uous improvement based on ongo<strong>in</strong>g<br />
expert review of exist<strong>in</strong>g data. Second, it has a comprehensive set of def<strong>in</strong>itions<br />
and rules of application that ensure uniform use. Third, it is multidiscipl<strong>in</strong>ary <strong>in</strong><br />
design and is pert<strong>in</strong>ent to all modern techniques of stage evaluation.<br />
Figure 5 shows the distribution of colorectal cancer TNM stages <strong>in</strong> males and<br />
females <strong>in</strong> Flanders for the years 2000 - 2001. Stage distributions <strong>in</strong> males and<br />
females show a very comparable pattern. These data also show that the stage<br />
distribution is very similar <strong>in</strong> the different age categories (not shown). This<br />
stag<strong>in</strong>g illustrates the extent of colorectal cancer at the time of diagnosis and<br />
enabled the classification of patients <strong>in</strong>to prognostically comparable categories.<br />
Although the importance of good stag<strong>in</strong>g is well-recognised, these data were<br />
not always passed on to the cancer registry. In addition, these data may have<br />
been <strong>in</strong>complete or miss<strong>in</strong>g from the medical files. These are possible reasons<br />
why the cancer registry encountered an important percentage of miss<strong>in</strong>g data.<br />
With the <strong>in</strong>troduction <strong>in</strong> 2003 of f<strong>in</strong>ancial reimbursement for multidiscipl<strong>in</strong>ary<br />
oncological consultations, it might be expected that these data will be more<br />
complete <strong>in</strong> the future because payment is only made if these data are<br />
completed.