Report in English with a Dutch summary (KCE reports 45A)

Report in English with a Dutch summary (KCE reports 45A) Report in English with a Dutch summary (KCE reports 45A)

10.08.2013 Views

26 Screening for Colorectal Cancer KCE reports vol.45 Figure 4: Invasive colorectal primary tumor localisations (n = 7.091, including appendix) in Flanders 2000 2001 (source: Vlaams Agentschap Zorg en Gezondheid 39) 2.4 STAGING The TNM staging system (Tumor, Node, Metastasis) 40, 41 of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (Union Internationale Contre le Cancer - UICC) is now the standard for colorectal cancer staging widely used by national, regional, and local tumor registries in the United States and internationally. In short, it is the international language of colorectal cancer staging in all disciplines. The TNM system has three additional advantages over other staging systems. First, it is data-driven and has a process in place for continuous improvement based on ongoing expert review of existing data. Second, it has a comprehensive set of definitions and rules of application that ensure uniform use. Third, it is multidisciplinary in design and is pertinent to all modern techniques of stage evaluation. Figure 5 shows the distribution of colorectal cancer TNM stages in males and females in Flanders for the years 2000 - 2001. Stage distributions in males and females show a very comparable pattern. These data also show that the stage distribution is very similar in the different age categories (not shown). This staging illustrates the extent of colorectal cancer at the time of diagnosis and enabled the classification of patients into prognostically comparable categories. Although the importance of good staging is well-recognised, these data were not always passed on to the cancer registry. In addition, these data may have been incomplete or missing from the medical files. These are possible reasons why the cancer registry encountered an important percentage of missing data. With the introduction in 2003 of financial reimbursement for multidisciplinary oncological consultations, it might be expected that these data will be more complete in the future because payment is only made if these data are completed.

KCE reports vol.45 Screening for Colorectal Cancer 27 Figure 5: Colorectal cancer stages in 2000 - 2001, TNM 5th edition 1997 (source: Vlaams Agentschap Zorg en Gezondheid 39) The older Dukes staging system 42 for CRC and its later modifications (mainly the Modified Dukes-Astler-Coller staging - MAC 43, 44) is a pathological staging based on resection of the tumor and measures the depth of invasion through the mucosa and bowel wall. It does not take into account the level of nodal involvement or the grade of the tumor. It is, however, still widely used in surgical publications in Belgium and other European countries. Based on different sources 40, 41, 45, 44 we produced a comprehensive overview of the TNM stages for CRC and their correlates with Dukes and MAC classifications (Table 4).

26 Screen<strong>in</strong>g for Colorectal Cancer <strong>KCE</strong> <strong>reports</strong> vol.45<br />

Figure 4: Invasive colorectal primary tumor localisations (n = 7.091,<br />

<strong>in</strong>clud<strong>in</strong>g appendix) <strong>in</strong> Flanders 2000 2001 (source: Vlaams<br />

Agentschap Zorg en Gezondheid 39)<br />

2.4 STAGING<br />

The TNM stag<strong>in</strong>g system (Tumor, Node, Metastasis) 40, 41 of the American Jo<strong>in</strong>t<br />

Committee on Cancer (AJCC) and the International Union Aga<strong>in</strong>st Cancer<br />

(Union Internationale Contre le Cancer - UICC) is now the standard for<br />

colorectal cancer stag<strong>in</strong>g widely used by national, regional, and local tumor<br />

registries <strong>in</strong> the United States and <strong>in</strong>ternationally. In short, it is the <strong>in</strong>ternational<br />

language of colorectal cancer stag<strong>in</strong>g <strong>in</strong> all discipl<strong>in</strong>es. The TNM system has<br />

three additional advantages over other stag<strong>in</strong>g systems. First, it is data-driven<br />

and has a process <strong>in</strong> place for cont<strong>in</strong>uous improvement based on ongo<strong>in</strong>g<br />

expert review of exist<strong>in</strong>g data. Second, it has a comprehensive set of def<strong>in</strong>itions<br />

and rules of application that ensure uniform use. Third, it is multidiscipl<strong>in</strong>ary <strong>in</strong><br />

design and is pert<strong>in</strong>ent to all modern techniques of stage evaluation.<br />

Figure 5 shows the distribution of colorectal cancer TNM stages <strong>in</strong> males and<br />

females <strong>in</strong> Flanders for the years 2000 - 2001. Stage distributions <strong>in</strong> males and<br />

females show a very comparable pattern. These data also show that the stage<br />

distribution is very similar <strong>in</strong> the different age categories (not shown). This<br />

stag<strong>in</strong>g illustrates the extent of colorectal cancer at the time of diagnosis and<br />

enabled the classification of patients <strong>in</strong>to prognostically comparable categories.<br />

Although the importance of good stag<strong>in</strong>g is well-recognised, these data were<br />

not always passed on to the cancer registry. In addition, these data may have<br />

been <strong>in</strong>complete or miss<strong>in</strong>g from the medical files. These are possible reasons<br />

why the cancer registry encountered an important percentage of miss<strong>in</strong>g data.<br />

With the <strong>in</strong>troduction <strong>in</strong> 2003 of f<strong>in</strong>ancial reimbursement for multidiscipl<strong>in</strong>ary<br />

oncological consultations, it might be expected that these data will be more<br />

complete <strong>in</strong> the future because payment is only made if these data are<br />

completed.

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