10.08.2013 Views

Report in English with a Dutch summary (KCE reports 45A)

Report in English with a Dutch summary (KCE reports 45A)

Report in English with a Dutch summary (KCE reports 45A)

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

<strong>KCE</strong> <strong>reports</strong> vol.45 Screen<strong>in</strong>g for Colorectal Cancer: Appendices 179<br />

Nr. Title Issued by Year Familial Adenomatous Polyposis<br />

(FAP) & related<br />

5 Guidel<strong>in</strong>es for the<br />

Prevention, Early<br />

Detection and<br />

Management of<br />

Colorectal Cancer 50<br />

Australian Cancer<br />

Network Colorectal<br />

Cancer Guidel<strong>in</strong>es<br />

Revision Committee<br />

2005 FS annually or biennially from age<br />

12 15 years to 30 35 years until<br />

polyposis develops.<br />

Colonoscopic screen<strong>in</strong>g is<br />

appropriate for families <strong>with</strong><br />

attenuated FAP, as recto-sigmoid<br />

spar<strong>in</strong>g surgery can be done <strong>in</strong> this<br />

variant of the disease.<br />

Once a causative APC mutation<br />

has been identified for the family,<br />

genetic test<strong>in</strong>g may be used to<br />

dist<strong>in</strong>guish mutation-positive and<br />

mutation-negative family members.<br />

Hereditary Non-Polyposis<br />

Colon Cancer (HNPCC)<br />

Screen<strong>in</strong>g of mutation<br />

carriers or <strong>in</strong>dividuals<br />

affected <strong>with</strong> HNPCCrelated<br />

tumours <strong>in</strong><br />

Amsterdampositive families<br />

should be by full<br />

colonoscopy performed<br />

annually or at least once<br />

every two years, beg<strong>in</strong>n<strong>in</strong>g at<br />

the age of 25 years or five<br />

years earlier than the age of<br />

diagnosis of the youngest<br />

affected member of the<br />

family (whichever is the<br />

earliest).<br />

Screen<strong>in</strong>g first-degree<br />

relatives of affected<br />

members <strong>in</strong> Amsterdam<br />

positive families where the<br />

mutation status is unknown<br />

is similar, although<br />

colonoscopy can be reduced<br />

to two-yearly. More distant<br />

relatives can be offered 5yearly<br />

colonoscopy.<br />

Personal history of CRC<br />

resection<br />

Intensive follow up for CRC<br />

should be considered for<br />

patients who have had<br />

potentially curable disease,<br />

although optimal<br />

<strong>in</strong>vestigation and pathways<br />

are yet to be firmly<br />

established.<br />

Personal history of<br />

colonpolyps<br />

All polyps should be<br />

at least sampled, and<br />

preferably removed.<br />

Synchronous polyps<br />

should be sought and<br />

removed.<br />

All patients <strong>with</strong><br />

colorectal neoplasia<br />

completely removed<br />

at colonoscopy<br />

should then be<br />

considered for<br />

colonoscopic<br />

surveillance<br />

accord<strong>in</strong>g to the<br />

follow<strong>in</strong>g protocols:<br />

<strong>with</strong><strong>in</strong> 1 y. follow<strong>in</strong>g<br />

<strong>in</strong>complete or<br />

possible <strong>in</strong>adequate<br />

exam<strong>in</strong>ation, for<br />

example <strong>in</strong> a subject<br />

<strong>with</strong> multiple<br />

adenomas (level II<br />

evidence)<br />

at 3 y. <strong>with</strong> large<br />

adenomas (>1 cm),<br />

adenomas <strong>with</strong> highgrade<br />

dysplasia,<br />

villous change <strong>in</strong><br />

adenomas, three or<br />

more adenomas, or<br />

aged 60 or more<br />

<strong>with</strong> a first-degre<br />

relative <strong>with</strong><br />

colorectal neoplasia<br />

(level II evidence)<br />

at 4 to 6 y. <strong>in</strong><br />

subjects <strong>with</strong>out the<br />

risk factors outl<strong>in</strong>ed<br />

above. (level III-3).<br />

Inflammatory bowel disease<br />

(IBD)<br />

- -<br />

Miscellaneous

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!