Report in English with a Dutch summary (KCE reports 45A)
Report in English with a Dutch summary (KCE reports 45A)
Report in English with a Dutch summary (KCE reports 45A)
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<strong>KCE</strong> <strong>reports</strong> vol.45 Screen<strong>in</strong>g for Colorectal Cancer: Appendices 179<br />
Nr. Title Issued by Year Familial Adenomatous Polyposis<br />
(FAP) & related<br />
5 Guidel<strong>in</strong>es for the<br />
Prevention, Early<br />
Detection and<br />
Management of<br />
Colorectal Cancer 50<br />
Australian Cancer<br />
Network Colorectal<br />
Cancer Guidel<strong>in</strong>es<br />
Revision Committee<br />
2005 FS annually or biennially from age<br />
12 15 years to 30 35 years until<br />
polyposis develops.<br />
Colonoscopic screen<strong>in</strong>g is<br />
appropriate for families <strong>with</strong><br />
attenuated FAP, as recto-sigmoid<br />
spar<strong>in</strong>g surgery can be done <strong>in</strong> this<br />
variant of the disease.<br />
Once a causative APC mutation<br />
has been identified for the family,<br />
genetic test<strong>in</strong>g may be used to<br />
dist<strong>in</strong>guish mutation-positive and<br />
mutation-negative family members.<br />
Hereditary Non-Polyposis<br />
Colon Cancer (HNPCC)<br />
Screen<strong>in</strong>g of mutation<br />
carriers or <strong>in</strong>dividuals<br />
affected <strong>with</strong> HNPCCrelated<br />
tumours <strong>in</strong><br />
Amsterdampositive families<br />
should be by full<br />
colonoscopy performed<br />
annually or at least once<br />
every two years, beg<strong>in</strong>n<strong>in</strong>g at<br />
the age of 25 years or five<br />
years earlier than the age of<br />
diagnosis of the youngest<br />
affected member of the<br />
family (whichever is the<br />
earliest).<br />
Screen<strong>in</strong>g first-degree<br />
relatives of affected<br />
members <strong>in</strong> Amsterdam<br />
positive families where the<br />
mutation status is unknown<br />
is similar, although<br />
colonoscopy can be reduced<br />
to two-yearly. More distant<br />
relatives can be offered 5yearly<br />
colonoscopy.<br />
Personal history of CRC<br />
resection<br />
Intensive follow up for CRC<br />
should be considered for<br />
patients who have had<br />
potentially curable disease,<br />
although optimal<br />
<strong>in</strong>vestigation and pathways<br />
are yet to be firmly<br />
established.<br />
Personal history of<br />
colonpolyps<br />
All polyps should be<br />
at least sampled, and<br />
preferably removed.<br />
Synchronous polyps<br />
should be sought and<br />
removed.<br />
All patients <strong>with</strong><br />
colorectal neoplasia<br />
completely removed<br />
at colonoscopy<br />
should then be<br />
considered for<br />
colonoscopic<br />
surveillance<br />
accord<strong>in</strong>g to the<br />
follow<strong>in</strong>g protocols:<br />
<strong>with</strong><strong>in</strong> 1 y. follow<strong>in</strong>g<br />
<strong>in</strong>complete or<br />
possible <strong>in</strong>adequate<br />
exam<strong>in</strong>ation, for<br />
example <strong>in</strong> a subject<br />
<strong>with</strong> multiple<br />
adenomas (level II<br />
evidence)<br />
at 3 y. <strong>with</strong> large<br />
adenomas (>1 cm),<br />
adenomas <strong>with</strong> highgrade<br />
dysplasia,<br />
villous change <strong>in</strong><br />
adenomas, three or<br />
more adenomas, or<br />
aged 60 or more<br />
<strong>with</strong> a first-degre<br />
relative <strong>with</strong><br />
colorectal neoplasia<br />
(level II evidence)<br />
at 4 to 6 y. <strong>in</strong><br />
subjects <strong>with</strong>out the<br />
risk factors outl<strong>in</strong>ed<br />
above. (level III-3).<br />
Inflammatory bowel disease<br />
(IBD)<br />
- -<br />
Miscellaneous