Report in English with a Dutch summary (KCE reports 45A)
Report in English with a Dutch summary (KCE reports 45A) Report in English with a Dutch summary (KCE reports 45A)
140 Screening for Colorectal Cancer: Appendices KCE reports vol.45 Informed consent following personal consultation with family practitioner or equivalent Standardised protocols and procedures with a single entry test and options for follow-up Systematic tracking and evaluation of all screening invitations (if used, testing frequency, results (including false positive and false negative rates), follow-up, and outcomes) Based on current evidence, the National Committee recommends, Screening be offered to a target population of adults aged 50 to 74 years of age, using unrehydrated Hemoccult II or equivalent as the entry test Individuals be screened at least every two years, recognizing that annual screening would have slight improvement in mortality reduction over biennial, but require increased resources Positive tests be followed up by colonoscopy, with options of barium enema and flexible sigmoidoscopy where appropriate (e.g. patient preference/availability of services) Despite the recommendations of the National Committee the government has not yet adopted a national screening program 587. There was however a pilot program in Alberta offering biennial screening to individuals over 50 588. In order to implement the recommendations of the National Committee, the Alberta cancer board has hosted an expert panel involving representatives from several disciplines, including representatives from Alberta Health and Welness and the two large regional health authorities in the province. Almost half of the colorectal cancers of Canada are located in the province of Ontario 589. Cancer Care Ontario, in collaboration with the Ontario Ministry of Health and Long-Term Care, the Institute for Clinical Evaluative Sciences, and the Ontario Association of Medical Laboratories conducted a one-year pilot project of population-based screening for colorectal cancer using the Fecal Occult Blood Test (FOBT) 590. The pilot project took place from March 2004 to March 2005 in 12 randomly selected regions in Ontario. The main goal of the project was to determine the best way to encourage Ontario residents aged 50 to 75 years and at average-risk of colorectal cancer, to be screened. The pilot compared two methods of recruitment: through recommendations from the family doctor to be screened, and through promotion and activities of the local public health unit. The project also looked at: variations in recruitment rates among the diverse geographic, socio-demographic, and linguistic communities of Ontario, including Northern Ontario and among non-English speakers attitudes about colorectal cancer screening with FOBT among primary care physicians, public health units, and persons who are eligible for screening selected indicators of system-capacity and resource-utilization, such as follow-up rates, waiting times for follow-up investigation, and cost of promotion and recruitment effectiveness of various strategies to promote screening
KCE reports vol.45 Screening for Colorectal Cancer: Appendices 141 other implementation and feasibility issues Despite strong evidence about early detection and prevention of colorectal cancer deaths through screening with the fecal occult blood test (FOBT), statistics show that Ontario s screening participation rates include only 15% in eligible individuals. The results of the project will be used to inform the development of a provincial colorectal cancer screening policy, enhancing the potential for highquality, accurate, and timely population-based colorectal cancer screening and follow-up program in Ontario In March 2006, Toronto launched a program to train nurses to perform flexible sigmoidoscopy. So far the program has trained six nurses at two sites in Toronto. In addition, the report from a one-year pilot project on FOBT has recently been submitted to the Ministry of Health and Long-Term Care (MOHLTC) with a request for funding for a provincial FOBT screening program. The design of the program is similar to that in the UK with a central program office, regional offices and colonoscopy hubs. There are also plans for an information system, quality assurance and ongoing monitoring of participation rates, positivity rates, referral rates, adverse events and evaluation of outcomes. In order to raise public awareness for colorectal cancer a National Colorectal Cancer Campaign was set up in 1997 and has become a national campaign 591. 7.13.2 Groups at increased or high risk The Ontario familial colon cancer registries collect personal and family health information from Ontario residents who have a family history of colorectal cancer. The registries participate in Cancer Family Registries (CFR), an international assembly made up of 10 participating sites from Australia, the United States and Canada. 7.14 NEW ZEALAND 7.14.1 Average risk groups The implications of a program for colon cancer screening for New Zealand were examined in 1998 by a National Working Party on Screening for Colorectal Cancer 592. The working party recommended against establishing a national population based screening program for colorectal cancer with FOBT, given the modest potential benefit, the considerable commitment of health sector resources and the small but real potential for harm. There was also a lack of evidence from randomised controlled trials that a screening program with other modalities such as flexible sigmoidoscopy, colonoscopy or double contrast barium enema will reduce the incidence of people dying from colorectal cancer. In order to update the conclusions of the working party on colorectal cancer screening, the New Zealand Ministry of Health s national screening unit requested New Zealand Health Technology Assessment (NZHTA) to undertake a systematic review of the new (since 1997) evidence on colorectal cancer screening 219. Consistent with the findings of the Working Party on Screening for Colorectal Cancer, high quality evidence was found that FOBT screening with the guaiacbased FOBT Hemoccult reduces mortality from colorectal cancer. FOBT as a screening test however raised several issues concerning other aspects of how
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<strong>KCE</strong> <strong>reports</strong> vol.45 Screen<strong>in</strong>g for Colorectal Cancer: Appendices 141<br />
other implementation and feasibility issues<br />
Despite strong evidence about early detection and prevention of colorectal<br />
cancer deaths through screen<strong>in</strong>g <strong>with</strong> the fecal occult blood test (FOBT),<br />
statistics show that Ontario s screen<strong>in</strong>g participation rates <strong>in</strong>clude only 15% <strong>in</strong><br />
eligible <strong>in</strong>dividuals.<br />
The results of the project will be used to <strong>in</strong>form the development of a<br />
prov<strong>in</strong>cial colorectal cancer screen<strong>in</strong>g policy, enhanc<strong>in</strong>g the potential for highquality,<br />
accurate, and timely population-based colorectal cancer screen<strong>in</strong>g and<br />
follow-up program <strong>in</strong> Ontario<br />
In March 2006, Toronto launched a program to tra<strong>in</strong> nurses to perform flexible<br />
sigmoidoscopy. So far the program has tra<strong>in</strong>ed six nurses at two sites <strong>in</strong><br />
Toronto. In addition, the report from a one-year pilot project on FOBT has<br />
recently been submitted to the M<strong>in</strong>istry of Health and Long-Term Care<br />
(MOHLTC) <strong>with</strong> a request for fund<strong>in</strong>g for a prov<strong>in</strong>cial FOBT screen<strong>in</strong>g<br />
program. The design of the program is similar to that <strong>in</strong> the UK <strong>with</strong> a central<br />
program office, regional offices and colonoscopy hubs. There are also plans for<br />
an <strong>in</strong>formation system, quality assurance and ongo<strong>in</strong>g monitor<strong>in</strong>g of<br />
participation rates, positivity rates, referral rates, adverse events and evaluation<br />
of outcomes.<br />
In order to raise public awareness for colorectal cancer a National Colorectal<br />
Cancer Campaign was set up <strong>in</strong> 1997 and has become a national campaign 591.<br />
7.13.2 Groups at <strong>in</strong>creased or high risk<br />
The Ontario familial colon cancer registries collect personal and family health<br />
<strong>in</strong>formation from Ontario residents who have a family history of colorectal<br />
cancer. The registries participate <strong>in</strong> Cancer Family Registries (CFR), an<br />
<strong>in</strong>ternational assembly made up of 10 participat<strong>in</strong>g sites from Australia, the<br />
United States and Canada.<br />
7.14 NEW ZEALAND<br />
7.14.1 Average risk groups<br />
The implications of a program for colon cancer screen<strong>in</strong>g for New Zealand<br />
were exam<strong>in</strong>ed <strong>in</strong> 1998 by a National Work<strong>in</strong>g Party on Screen<strong>in</strong>g for<br />
Colorectal Cancer 592. The work<strong>in</strong>g party recommended aga<strong>in</strong>st establish<strong>in</strong>g a<br />
national population based screen<strong>in</strong>g program for colorectal cancer <strong>with</strong> FOBT,<br />
given the modest potential benefit, the considerable commitment of health<br />
sector resources and the small but real potential for harm. There was also a<br />
lack of evidence from randomised controlled trials that a screen<strong>in</strong>g program<br />
<strong>with</strong> other modalities such as flexible sigmoidoscopy, colonoscopy or double<br />
contrast barium enema will reduce the <strong>in</strong>cidence of people dy<strong>in</strong>g from<br />
colorectal cancer.<br />
In order to update the conclusions of the work<strong>in</strong>g party on colorectal cancer<br />
screen<strong>in</strong>g, the New Zealand M<strong>in</strong>istry of Health s national screen<strong>in</strong>g unit<br />
requested New Zealand Health Technology Assessment (NZHTA) to<br />
undertake a systematic review of the new (s<strong>in</strong>ce 1997) evidence on colorectal<br />
cancer screen<strong>in</strong>g 219.<br />
Consistent <strong>with</strong> the f<strong>in</strong>d<strong>in</strong>gs of the Work<strong>in</strong>g Party on Screen<strong>in</strong>g for Colorectal<br />
Cancer, high quality evidence was found that FOBT screen<strong>in</strong>g <strong>with</strong> the guaiacbased<br />
FOBT Hemoccult reduces mortality from colorectal cancer. FOBT as a<br />
screen<strong>in</strong>g test however raised several issues concern<strong>in</strong>g other aspects of how