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Report in English with a Dutch summary (KCE reports 45A)

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132 Screen<strong>in</strong>g for Colorectal Cancer: Appendices <strong>KCE</strong> <strong>reports</strong> vol.45<br />

designed accord<strong>in</strong>g to the EU recommendations and focused on asymptomatic<br />

<strong>in</strong>dividuals aged over 50, <strong>with</strong> first FOBT, provided and <strong>in</strong>terpreted by GP s, and<br />

if positive patients are referred for colonoscopy performed by a<br />

gastroenterologist. The expenses are covered by health <strong>in</strong>surance 544.<br />

After 4 years the global data show that about 20% of the targeted population<br />

participates <strong>in</strong> the program. 97% of GPs <strong>in</strong> the country jo<strong>in</strong>ed the program and<br />

20 % of them reached 50% FOBT coverage of targeted population. The data<br />

from practices show that 80-90 % of patients return the test <strong>with</strong><strong>in</strong> three<br />

months. However, 10-20 % refuse colonoscopy when FOBT was positive.<br />

7.6.2 Groups at <strong>in</strong>creased or high risk<br />

7.7 FRANCE<br />

People at high risk of hav<strong>in</strong>g colorectal cancer are recruited by GPs or<br />

gastroenterologists for an early colonoscopy or FOBT test<strong>in</strong>g at age of 40 and<br />

further on a yearly basis although the approach can vary <strong>in</strong>dividually.<br />

7.7.1 Average risk groups<br />

In 1998, the Agence nationale d accréditation et d évaluation en santé<br />

(ANAES) recommended <strong>in</strong> a consensus conference the <strong>in</strong>troduction of an<br />

organised screen<strong>in</strong>g program for <strong>in</strong>dividuals between 50 and 74 years by means<br />

of a FOBT test every two years 545. In 2002, 22 departments (out of 95) have<br />

been selected for a pilot project. Follow<strong>in</strong>g the positive experience <strong>in</strong> those<br />

departments, colorectal cancer screen<strong>in</strong>g <strong>with</strong> FOBT was extended to 50<br />

departments <strong>in</strong> 2005 and is planned to be nationally implemented by 2007.<br />

Between 2002 and 2004, 2.700.000 persons were <strong>in</strong>vited and 716.000<br />

participated (+/ 26%) 546. The average participation rate <strong>in</strong> departments <strong>with</strong> an<br />

activity of more than 1 year and hav<strong>in</strong>g <strong>in</strong>vited more that 80 % of the population<br />

of the department was 33 %. It also appeared that the participation rate<br />

<strong>in</strong>creases <strong>with</strong> the duration of the program. In the department Haut Rh<strong>in</strong> a<br />

participation rate of 53,13 % (2006) was reached 547.<br />

A coupled strategy is used 548. First, <strong>in</strong>vitation letters are sent to <strong>in</strong>dividuals from<br />

the target group by a central adm<strong>in</strong>istration, the structure de gestion<br />

départemental 549. An <strong>in</strong>formation leaflet and a brief questionnaire are <strong>in</strong>cluded<br />

to the <strong>in</strong>vitation letter <strong>in</strong> order to identify the persons that have to be excluded<br />

from the screen<strong>in</strong>g program. Furthermore a self-adhesive label <strong>with</strong> the<br />

identification data is sent to the <strong>in</strong>dividual. The <strong>in</strong>dividual has to get the test<br />

from the GP, who has to expla<strong>in</strong> the objectives of the test to allow the patient<br />

to grasp its use and the consequences <strong>in</strong> case of a positive test result. The test<br />

will be realised at the <strong>in</strong>dividual s home. Afterwards <strong>in</strong>dividuals have to send the<br />

test to a central laboratory for analysis 550 (centre de lecture). These<br />

laboratories send the test results to the central adm<strong>in</strong>istration. The central<br />

adm<strong>in</strong>istration forwards the results to the patient and the GP. Those <strong>with</strong> a<br />

positive test result are recommended to undergo a colonoscopy. Individuals<br />

who underwent a colonoscopy are excluded from screen<strong>in</strong>g for the next 5<br />

years.<br />

If persons did not get tested after the first <strong>in</strong>vitation letter, a rem<strong>in</strong>der <strong>with</strong> a<br />

test is sent by mail by the central adm<strong>in</strong>istration to those <strong>in</strong>dividuals from the<br />

eligible target population that did not explicitly refuse to undergo the test. The<br />

GP has to <strong>in</strong>dicate the persons that are not eligible to get screened or the<br />

persons that refused the test to the central adm<strong>in</strong>istration. GP s are paid a fixed

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