Lab Safety Manual - UCLA - Environment, Health & Safety

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esistant storage cabinet or, in many cases, in laboratory grade refrigerator or freezer that are designed for flammable and reactive chemicals. Pyrophoric chemicals are a special classification of reactive materials that spontaneously combust when in contact with air and require laboratoryspecific training. Flame-resistant laboratory coats must always be worn when working with pyrophoric chemicals. HEALTH HAZARDS Cal/OSHA uses the following definition for health hazards: The term „health hazard‟ includes chemicals which are carcinogens, toxic or highly toxic agents, reproductive toxins, irritants, corrosives, sensitizers, hepatotoxins, nephrotoxins, neurotoxins, agents which act on the hematopoietic systems, and agents which damage the lungs, skin, eyes, or mucous membranes. The major classes of “hazardous” and “particularly hazardous substances” and their related health and safety risks are detailed below. Corrosive Substances As a health hazard, corrosive substances cause destruction of, or alterations in, living tissue by chemical action at the site of contact. Major classes of corrosive substances include: Strong acids – e.g., sulfuric, nitric, hydrochloric and hydrofluoric acids Strong bases – e.g., sodium hydroxide, potassium hydroxide and ammonium hydroxide Dehydrating agents – e.g., sulfuric acid, sodium hydroxide, phosphorus pentoxide and calcium oxide Oxidizing agents – e.g., hydrogen peroxide, chlorine and bromine. Symptoms of exposure for inhalation include a burning sensation, coughing, wheezing, laryngitis, shortness of breath, nausea, and vomiting. For eyes, symptoms include pain, blood shot eyes, tearing, and blurring of vision. For skin, symptoms may include reddening, pain, inflammation, bleeding, blistering and burns. As a physical hazard, corrosive substances may corrode materials they come in contact with and may be highly reactive with other substances. It is important to review information regarding the materials they may corrode, and their reactivity with other substances, as well as information on health effects. In most cases, these materials should be segregated from other chemicals and require secondary containment when in storage. Irritants Irritants are defined as non-corrosive chemicals that cause reversible inflammatory effects on living tissue by chemical action at the site of contact. A wide variety of organic and inorganic compounds, including many chemicals that are in a powder or crystalline form, are irritants. The most common example of an irritant may be ordinary smoke which can irritate the nasal passages and respiratory system. Consequently, eye and skin contact with all laboratory chemicals should always be avoided. Symptoms of exposure can include reddening or discomfort of the skin and irritation to respiratory systems. Chemical Hygiene Plan 3-3 January 2013
Sensitizers A sensitizer (allergen) is a substance that causes exposed people to develop an allergic reaction in normal tissue after repeated exposure to the substance. Examples of sensitizers include diazomethane, chromium, nickel, formaldehyde, isocyanates, arylhydrazines, benzylic and allylic halides, and many phenol derivatives. Sensitizer exposure can lead to all of the symptoms associated with allergic reactions, or can increase an individual‟s existing allergies. Hazardous Substances with Toxic Effects on Specific Organs Substances included in this category include: Hepatotoxins – i.e., substances that produce liver damage, such as nitrosamines and carbon tetrachloride Nephrotoxins – i.e., agents causing damage to the kidneys, such as certain halogenated hydrocarbons Neurotoxins – i.e., substances which produce their primary toxic effects on the nervous system, such as mercury, acrylamide and carbon disulfide Agents which act on the hematopoietic system – e.g., carbon monoxide and cyanides which decrease hemoglobin function and deprive the body tissues of oxygen Agents which damage lung tissue – e.g., asbestos and silica. Symptoms of exposure to these materials vary. Staff working with these materials should review the SDS for the specific material being used and should take special note of the associated symptoms of exposure. Particularly Hazardous Substances OSHA recognizes that some classes of chemical substances pose a greater health and safety risk than others. To differentiate this different risk characteristic, OSHA identifies two categories of hazardous chemicals: 1. hazardous chemicals; and 2. particularly hazardous substances. Substances that pose such significant threats to human health are classified as "particularly hazardous substances" (PHSs). The OSHA <strong>Lab</strong>oratory Standard and Cal/OSHA regulation require that special provisions be established to prevent the harmful exposure of researchers to PHSs, including the establishment of designated areas for their use. See <strong>UCLA</strong>‟s Particularly Hazardous Substances Policy (Appendix E) for more information, which also includes a list of common particularly hazardous chemicals used inside laboratories. Particularly hazardous substances are divided into three primary types: 1. Acute Toxins; 2. Reproductive Toxins; and 3. Carcinogens. Chemical Hygiene Plan 3-4 January 2013
Page 2 and 3: Laboratory Safety Manual Office of
Page 4 and 5: esponse. This information is intend
Page 6 and 7: are noted, and provide training and
Page 8 and 9: IIPP
Page 10 and 11: Chemical Hygiene Plan January 2013
Page 12 and 13: Table of Contents Chapter 1: Introd
Page 14 and 15: Chapter 1: Introduction Purpose UCL
Page 16 and 17: All personnel, including PIs/Labora
Page 18 and 19: c. Preparing SOPs and performing li
Page 20 and 21: Chapter 2: Chemical Hazard Communic
Page 22 and 23: EMPLOYEE INFORMATION AND TRAINING E
Page 24 and 25: Chapter 3: Classes of Hazardous Che
Page 28 and 29: Acute Toxins Substances that have a
Page 30 and 31: nanomaterials are used as fine powd
Page 32 and 33: Chapter 4: How to Reduce Exposures
Page 34 and 35: of the nine readings must be at lea
Page 36 and 37: EH&S requires that each laboratory
Page 38 and 39: EH&S policy requires each laborator
Page 40 and 41: An annual refresher is required for
Page 42 and 43: Never use mouth suction for pipetti
Page 44 and 45: Chapter 5: Chemical Exposure Assess
Page 46 and 47: the proper respiratory equipment an
Page 48 and 49: Physician’s Written Opinion For e
Page 50 and 51: Chapter 6: Inventory, Labeling, Sto
Page 52 and 53: Chemical Storage & Segregation Esta
Page 54 and 55: flammable solvent. Other common haz
Page 56 and 57: fuel-gas cylinders securely in the
Page 58 and 59: Chapter 7: Training Regulatory Requ
Page 60 and 61: Resources EH&S has a number of tool
Page 62 and 63: Chapter 8: Inspections and Complian
Page 64 and 65: and safety training, including safe
Page 66 and 67: Chapter 9: Hazardous Chemical Waste
Page 68 and 69: The manufacturer‟s SDS provides d
Page 70 and 71: Peroxide Forming Chemicals Peroxide
Page 72 and 73: appropriate lab coat, gloves and ey
Page 74 and 75: BENCH TOP TREATMENT EPA regulations
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Chapter 10: Accidents and Chemical
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Chemical Spills Chemical spills can
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Appendices Chemical Hygiene Plan Ja
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Appendix A: General Rules for Labor
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UNSAFE LABORATORY HABITS Personal P
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Appendix B: Sample Safety Data Shee
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Sample SDS, cont. Obtain SDS from t
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Appendix C: Container Labeling Chem
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Appendix D: SOP Instructions and Te
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Sample SOP Template Obtain this for
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Sample SOP Template, cont. Obtain t
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Sample SOP Template, cont. Obtain t
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Appendix E: UCLA Particularly Hazar
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substances or generalized over a gr
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E. Engineering Controls 1. Bench to
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educe exposure. If levels cannot be
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4. It is listed in either Group 2A
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A T T A C H M E N T C Listed Carcin
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Appendix F: Regulated Carcinogens C
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Appendix G: Respiratory Hazard Asse
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Appendix H: Peroxide Forming Chemic
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Appendix I: EH&S Safety Training Ma
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Appendix J: Employee Training Histo
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Appendix K: Site-Specific Training
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Appendix L: Laboratory Inspection C
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Laboratory Inspection Checklist, co
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Appendix M: Segregation of Incompat
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Appendix N: Hazardous Waste Pick-Up
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Appendix O: Spill Clean-up Procedur
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Appendix P: Lab Emergency Poster Ob
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Appendix Q: Policy 905 - Research L
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B. Protective gloves must be worn w
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Appendix R: NanoTool Kit Chemical H
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Chemical Hygiene Plan R-3 January 2
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Chemical Hygiene Plan R-11 January
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Appendix S: Facilities Service Cons
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Appendix T: PPE Issuance Form Chemi
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Appendix U: Glossary ACGIH - The Am
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GENERAL VENTILATION - Also known as
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MUTAGEN - Anything that can cause a
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Lab Specific SOPs
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Inspection Records
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Resources
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3. Outline Lab Safety Training Requ
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