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1850 MANUAL OF PATENT EXAMINlNG PROCEDURE<br />
<strong>The</strong> search fee which the applicant is required to<br />
pay is intended to compensate the International<br />
Searching Auth<strong>or</strong>ity f<strong>or</strong> carrying ont an international<br />
search on the international application, but only where<br />
the international application meets the "requirement<br />
of unity of invention". That means that the international<br />
application must relate to only one invention <strong>or</strong><br />
must relate to a group of inventions which are so<br />
linked as to f<strong>or</strong>m a single general inventive concept<br />
(PCT Articles 3(4)(iii) and 17(3)(a».<br />
If the International Searching Auth<strong>or</strong>ity finds that<br />
the international application does not comply with the<br />
requirement of unity ofinvention, the applicant will<br />
be invited to pay additional search fees. <strong>The</strong> International<br />
Searching Auth<strong>or</strong>ity will specify the reasons f<strong>or</strong><br />
its findings and indicate the number of additional fees<br />
to bepaid (pCT Rules 40.1, 40.2(a) and (bj), Such<br />
additional fees are payable directly to the International<br />
Searching Auth<strong>or</strong>ity which is conducting the<br />
search, either the United States <strong>Patent</strong> and Trademark<br />
Office <strong>or</strong> European <strong>Patent</strong> Office, within the. time<br />
limit fixed, which must not be sh<strong>or</strong>ter than 15 days, if<br />
the applicant's address is in the same country as the<br />
International Searching Auth<strong>or</strong>ity; <strong>or</strong> 30 days, if<br />
applicant's address is in a. country different than the<br />
country of the International Searching Auth<strong>or</strong>ity; and<br />
not longer than 45 days from the date of the invitation<br />
(PCT Rule 40.3). <strong>The</strong> search fee amounts f<strong>or</strong> the U.S.<br />
and the European <strong>Patent</strong> Office are found in each<br />
weekly edition of the Official Gazette.<br />
<strong>The</strong> International Searching Auth<strong>or</strong>ity will establish<br />
the international search rep<strong>or</strong>t on those parts of<br />
international application which relate to the "main<br />
invention," that is, the invention <strong>or</strong> the group of<br />
inventions so linked as to f<strong>or</strong>m a single general inventive<br />
concept first mentioned in the claims (PCT Article<br />
17(3)(a». M<strong>or</strong>eover, the international search<br />
rep<strong>or</strong>t will be established also on those parts of the<br />
international application which relate to any invention<br />
(<strong>or</strong> any group of inventions so linked as to f<strong>or</strong>m a single<br />
general inventive concept) in respect of which the<br />
applicant has paid any additional fee within the prescribed<br />
time limits.<br />
Any applicant may pay the additional fee under<br />
protest, that is, accompanied by a reasoned statement<br />
to the effect that the international application complies<br />
with the requirementof unity of invention <strong>or</strong> that<br />
the amount of the required additional fee is excessive<br />
August2001<br />
1800-64<br />
(PCT Rule 4O.2(c». Any such protest filed with the<br />
U.S. International Searching Auth<strong>or</strong>ity will be examined<br />
and decided by a Technology Center Direct<strong>or</strong> (37<br />
CFR 1.477). To the extent that the applicant's protest<br />
is found to be justified, total <strong>or</strong> partial reimbursement<br />
of the additional fee will be made. On the request of<br />
the applicant, the text of both the protest and the decision<br />
thereon is sent to the designated Offices together<br />
with the international search rep<strong>or</strong>t (37 CFR 1.477).<br />
Where, within the prescribed time limit, the applicant<br />
does not pay any additional fees <strong>or</strong> only pays<br />
some of the additional fees indicated.'certain parts of<br />
the international application will consequently not be<br />
searched. <strong>The</strong> lack of an international search rep<strong>or</strong>t in<br />
respect of such parts of the international application<br />
will, in itself, have no influence on the validity ofthe<br />
international application and processing of the international<br />
application will continue, both in the international<br />
and in the national (regional) phases. <strong>The</strong><br />
unsearched claims, upon entry into the national stage,<br />
will be considered by the examiner and may be the<br />
subject of a holding oflack ofunity ofinvention.<br />
See MPEP § 1875.01 f<strong>or</strong> telephone unity practice.<br />
It applies in the same manner under Chapter I.<br />
UNITY OF INVENTION . NUCLEOTIDE SE·<br />
QUENCES<br />
Under 37 CPR 1.475 and 1.499 et seq., when<br />
claims do not comply with the requirement of unity of<br />
invention, i.e., when the claimed subject matter does<br />
not involve "one <strong>or</strong> m<strong>or</strong>e of the same <strong>or</strong> c<strong>or</strong>responding<br />
special technical features," 37 CFR 1.475(a), an<br />
additional fee is required to maintain the claims in the<br />
same application. 37 CFR 1.476 (b).<br />
<strong>The</strong> Commissioner has decided sua sponte to partially<br />
waive 37 CFR 1.475 and 1.499 et seq. to permit<br />
applicants to claim up to ten (10) nucleotide<br />
sequences that do not have the same <strong>or</strong> c<strong>or</strong>responding<br />
special technical feature without the payment of an<br />
additional fee. <strong>The</strong> PCT permits inventions that lack<br />
unity of invention to be maintained in the same international<br />
application f<strong>or</strong> payment of additional fees.<br />
Thus, in international applications, f<strong>or</strong> each group f<strong>or</strong><br />
which applicant has paid additional international<br />
search and/<strong>or</strong> preliminary examination fees, the<br />
USPTO has determined that up to four (4) such additional<br />
sequences per group is a reasonable number f<strong>or</strong><br />
examination. Further, claims directed to the selected