Mathematical Modelling and Anatysis of Dynamic Behaviour of a Fed

ln rhis wo.k, the substrale fbed rale. pH, and temperatufe
sere conrrolled using PID conrolleE The profiles of the
outpul vadables under nominal opemting condition where
constdi glucose feed are used duritg the fed-batch
opemtion. are illustrated in Figure ll lo Figure 19. Noletbat
both biomass and penicillin concentmtions had been
improved by adding a slow glucose lbed into the batch
fermenter. The controlled supply of gl cose enabled bolb
giowrh and penicillin production ro lake place
simultaneously Ii].
By including PID contolle.s in ftesystem, fte values ofPH
and temperalure were ma;nlained close !o their desired set
poinrs. Compared io the results withoul controllers, rbe
variaiions from the set-point values had been reduced As I
result, the overall perfonnance of lbe fe.mentation Process
was improved.Thh proved the importaice ofcontmlsystenr
Conclusion
An unstructurcd model for a fed'barch Penic;llin G
fe.mentatioo process had been develo!€d in this sludy Tbis
mathematical model includes additional inpul va.iables like
feed flow rale of substmte. pH, temperature. aemirot rate,
agitalion power as well as oxtput lariables such as CO,
evolution and heat generation terms. The model was
simulated in MATLAB environmenl and analyses of lhe
dynamic behaviou.of fie process were carried our. F.om fte
observation, a good agreement was shown bellveen the
r$ultsobtaired in this study and lbe literalure
Acknowledgements
The aurhors wish to thank Prol Ali Cinar and Dr Cenk
Undey for rheir rechnical support on rhis work This prcject
is funded by the Ministry of Science, Te.hnology and the
Envircnment alrd UniveN;d Teknoiogi Malaysia through
UTM'PrP Schola$hjps and IRPA research granr.
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