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The Semi-Living' and 'Partial Life'

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Partial Life<br />

edited by Oron Catts <strong>and</strong> Ionat Zurr<br />

Introduction<br />

'<strong>The</strong> <strong>Semi</strong>-<strong>Living'</strong> <strong>and</strong> <strong>'Partial</strong> <strong>Life'</strong> 

<br />

This Living Book is partially living – it is about the<br />

semi-living <strong>and</strong> partial lives, about tissues without a<br />

body. While the biological body cannot survive without<br />

organs <strong>and</strong> cells, the latter two can survive in a<br />

technological body, which has been removed <strong>and</strong><br />

separated from their original biological body. <strong>The</strong>y are<br />

living fragments of biological bodies, forms of lab-grown<br />

life which have been reconfigured, mixed <strong>and</strong> remixed,<br />

reappropriated, recontextualised <strong>and</strong> instrumentalised.<br />

<strong>The</strong> semi-living thus require a different epistemological<br />

<strong>and</strong> ontological underst<strong>and</strong>ing as well as a different<br />

consideration <strong>and</strong>, by extension, a different taxonomy of<br />

life. <strong>The</strong> liminality of this kind of technological<br />

approach to life can lead to a form of fetishism, which<br />

we call Neolifism. <strong>The</strong> semi-living <strong>and</strong> partial lives are<br />

a new class of objects or beings. In most cases they<br />

consist of living <strong>and</strong> non-living materials; of cells <strong>and</strong>/or<br />

tissues from a complex organism which have been<br />

grown over, or into, constructed scaffolds <strong>and</strong><br />

subsequently kept alive with an artificial support. <strong>The</strong>y<br />

are both similar <strong>and</strong> different from other human<br />

artefacts (Homo sapiens’ extended phenotype), such as


constructed objects <strong>and</strong> selectively bred domestic plants<br />

<strong>and</strong> animals (both pets <strong>and</strong> husb<strong>and</strong>ry). <strong>The</strong>se entities<br />

are living biological systems which have been<br />

artificially designed <strong>and</strong> which, in their isolation,<br />

construction, growth <strong>and</strong> maintenance, need<br />

technological intervention.<br />

‘<strong>The</strong> semi-living’ <strong>and</strong> ‘partial life’ can be seen as<br />

interchangeable terms. <strong>The</strong>re are, however, some<br />

nuances between the two. <strong>Semi</strong>-living entities are<br />

usually shaped as forms that are not recognisable as<br />

being part of any particular body; partial life can be<br />

recognised as parts (such as an ear or tissue) of the<br />

whole of a living being. Symbolically, on the continuum<br />

of man-made life, semi-living entities are nearer to the<br />

constructed side of the scale, while objects of partial life<br />

find themselves closer to the grown side of the scale.<br />

<strong>The</strong> ‘population’ of what can be referred to as partial<br />

life <strong>and</strong> semi-living entities has proliferated to reach a<br />

vast amount of cells <strong>and</strong> tissues that are currently<br />

living <strong>and</strong> growing outside of the organisms from which<br />

they originated. A rough estimate would put the<br />

biomass of the living cells <strong>and</strong> tissues which are<br />

disassociated from the original bodies that once hosted<br />

them at millions of tons. In addition, there exist tons of<br />

fragments of bodies (cells, tissues, organs) that are<br />

maintained in suspended animation in cryogenic<br />

conditions. All of this biomass requires an intensive<br />

technological intervention to prevent its transformation<br />

to a non-living state. <strong>The</strong>se beings are rarely referred to<br />

as subjects; their existence, supported as it is by the<br />

technoscientific project, is indicative of the<br />

transformation of life into raw material that manifests<br />

itself through utilitarian <strong>and</strong> economic value.<br />

This edition of the Living Book attempts ‘to give a voice’


to such semi-living beings by presenting their history<br />

<strong>and</strong> selected examples of their use (<strong>and</strong> existence), with<br />

the aim of highlighting the problematics they raise --<br />

which is also a reflection of the current state of our<br />

society. This is a society which is attempting to cope<br />

with the growing gap between the rapidly increasing<br />

knowledge <strong>and</strong> the technological ability to manipulate<br />

life on the one h<strong>and</strong>, <strong>and</strong> the deeply rooted attitudes<br />

towards life which are still lurking behind on the other.<br />

It is a society that may be facing its own extinction as a<br />

result of the ecological crisis <strong>and</strong> that is in urgent need<br />

of reconsidering the Judeo-Christian view of our<br />

supposed dominion over ‘nature’ in favour of a more<br />

post-humanist agenda. Having control over life, its<br />

processes <strong>and</strong> the environment as a whole has always<br />

been the basis of human endeavour. Yet the attitudes<br />

towards life are now changing as a result of the<br />

accumulation of scientific knowledge <strong>and</strong> technological<br />

capabilities -- both of which are mounting up with an<br />

increasing speed <strong>and</strong> scale of manipulation. A<br />

choreographed interplay between hype <strong>and</strong> actuality is<br />

overlaid on a public which is being bombarded with<br />

information which can potentially excite <strong>and</strong> disturb,<br />

but which is also easily forgotten. As the perception of<br />

the level of control over the matter of life increases, it<br />

seems that, whereas previously biologists were<br />

applying their underst<strong>and</strong>ing of engineering to the life<br />

sciences, now it is the engineers who are force-fitting<br />

engineering methodologies into living systems. Life is<br />

becoming bio-matter, waiting to be engineered.<br />

<strong>The</strong> Historical Perspective on the <strong>Semi</strong>-Living<br />

<strong>The</strong> precursors of the semi-living can be identified in<br />

whole bodies, which are sustained alive in technoscientific<br />

‘bodies’. With the industrial revolution <strong>and</strong>


the rise of the age of the machines, coupled with the<br />

naissance of the systematic underst<strong>and</strong>ing of life, the<br />

late nineteenth century witnessed the birth of biology<br />

as engineering, <strong>and</strong> the union of life <strong>and</strong> technology.<br />

<strong>The</strong> introduction of industrial baby <strong>and</strong> poultry<br />

incubators coincided with the birth of tissue culturing<br />

<strong>and</strong> the appearance of the semi-living. <strong>The</strong> coming<br />

together of life <strong>and</strong> technology manifested itself in<br />

strange ways, as indicated by the example of poultry<br />

incubators <strong>and</strong> the history of Cyphers Incubator<br />

Company. <strong>The</strong> story of the development <strong>and</strong> acceptance<br />

of human incubators (whereby an incubator can be seen<br />

as a techno-scientific ‘body’, or ‘epi-body’), <strong>and</strong><br />

especially the way in which they were introduced to<br />

America, is fascinating. It highlights how<br />

technologically augmented life, even in human babies,<br />

needed to be articulated <strong>and</strong> negotiated before such<br />

babies became ‘transformed’ from objects of<br />

entertainment to subject of care. <strong>The</strong> incubator was<br />

initially ‘modeled after [the] chick incubator’ by<br />

Stéphane Tarnier. <strong>The</strong> ‘American father’ of<br />

neonatology, Dr Martin A. Couney, was a European<br />

physician who promoted the idea of mechanical<br />

incubators as an aid to prolonging <strong>and</strong> saving the lives<br />

of the newly born, who would have otherwise died. <strong>The</strong><br />

creation of the ‘need’ for a device that would orchestrate<br />

the ‘passage’ of an infant from a fragile ambiguous zone<br />

into the realm of a person is a complex story. One<br />

impetus for developing the incubator was the desire to<br />

halt population decline. <strong>The</strong>re was a need not only to<br />

save those otherwise doomed ‘lives’, but also to<br />

strengthen the mother-child bond (which was directly<br />

related to infant survival). <strong>The</strong> initial design of the<br />

incubators was already geared not solely for the<br />

purposes of biomedicine: the incubator was also<br />

positioned as an aesthetic device, aimed at creating


certain meanings out of the technique <strong>and</strong> the life it<br />

sustained, <strong>and</strong> at generating empathy towards the bare<br />

life on display. Incubators were promoted in Europe<br />

<strong>and</strong> the USA via public fairs, during which the<br />

enthusiastic public had to pay for admission to watch<br />

the show of the ‘Infant Incubators with Living Infants’.<br />

Couney had a permanent incubator show at Luna Park<br />

on Coney Isl<strong>and</strong>, New York, from 1903 to 1943, <strong>and</strong> was<br />

instrumental in Cornell University’s New York<br />

Hospital opening the city’s first neonatal ward.<br />

Why did a successfully working technology, which<br />

saved so many lives, take such a long time to be<br />

accepted by the medical community, while it was<br />

thriving within the realm of public entertainment?<br />

Some say that Couney never intended for the<br />

technology to become widely available as this would<br />

have ended his ability to profit from it by charging the<br />

public to come <strong>and</strong> see the living display. It may have<br />

been that the context of the Luna Park exhibition <strong>and</strong><br />

the showmanship involved prevented the medical<br />

establishment from accepting this technology. <strong>The</strong>se<br />

are interesting <strong>and</strong> valid points. However, we want to<br />

suggest that such vexed cases in which liminal beings<br />

are in transition towards not just bare life but also<br />

towards scientific <strong>and</strong> moral classification, have to be<br />

articulated initially via aesthetic rather than scientific<br />

modes of presentation. A similar story is evident in the<br />

‘cabinet of curiosities’, which served as a prelude to the<br />

natural history-refined taxonomy. To a certain extent,<br />

the neonatal technology can be said to have assisted in<br />

‘classifying’ premature babies as belonging in the realm<br />

of the living <strong>and</strong> the human, <strong>and</strong> therefore as persons.<br />

As a result, the context where those new lives were<br />

dependent on their epi-bodies had to be dramatically


changed -- from the realm of entertainment to that of<br />

biomedicine. Today the new cabinet of curiosities is<br />

being constructed, or grown again, in the form of new<br />

technologically-dependent <strong>and</strong> yet still to be classified<br />

lives, lives which are being created in scientific<br />

laboratories by emerging technologies. <strong>The</strong>se new<br />

entities do not conform or fit with classifications<br />

propounded by natural history museums, let alone with<br />

our traditional underst<strong>and</strong>ing of what life is <strong>and</strong> what<br />

it means to be alive.<br />

<strong>The</strong> History of Tissue Culture<br />

<strong>The</strong> idea of the cellular body dates back to Aristotle<br />

(340 BC) <strong>and</strong> <strong>The</strong>ophrastus (320 BC), who both<br />

described animals <strong>and</strong> plants as being made up of<br />

unified elements: blood <strong>and</strong> sap, flesh <strong>and</strong> fibre, nerves<br />

<strong>and</strong> veins, bone <strong>and</strong> wood. Later, scientists such as<br />

Malpighi (1675) <strong>and</strong> Grew (1682) theorised that these<br />

elements were literally ‘woven’ (tissé) into tissues of<br />

still finer elements. In 1667, Robert Hooke, using one of<br />

the earliest microscopes, observed cell structures in a<br />

thin slice of cork. He coined the word ‘cell’, referring to<br />

a structure that reminded him of a honeycomb. Parts of<br />

bodies have been sustained, grown <strong>and</strong> cultured for<br />

more than a hundred years now. We are not talking<br />

about the 18th century Galvani-style reanimation by<br />

external power, but rather about the continuation of life<br />

processes <strong>and</strong> of the functions of parts that have been<br />

removed from bodies -- be it organs, tissues <strong>and</strong> cells.<br />

Fluttering attempts to keep body fragments alive were<br />

performed by in 1885 Willhelm Roux, who sustained<br />

embryonic chicken tissue alive for short periods of time,<br />

<strong>and</strong> by Ross G. Harrison, who grew a frog’s nerve cell<br />

outside of the body in 1907. <strong>The</strong> ongoing existence of<br />

living fragments, i.e., of the semi-living, appeared with


the more systematic <strong>and</strong> sometime occult practice of<br />

Alexis Carrel, who cultured cells, tissues <strong>and</strong><br />

eventually organs between 1913 <strong>and</strong> the 1940s. Carrel<br />

was a well-known <strong>and</strong> respected scientist who advanced<br />

the medical field in the area of new techniques of<br />

suturing arteries as well as transplantation <strong>and</strong> tissue<br />

culturing. He won the Nobel Prize for Medicine in 1912.<br />

Carrel was a complex <strong>and</strong> controversial figure, who<br />

pushed the ontological implications of his discoveries to<br />

some rather extreme <strong>and</strong> morally dubious places -- far<br />

from their strictly biomedical or even scientific realms<br />

<strong>and</strong> into ontologically, politically <strong>and</strong> ethically<br />

questionable ones.<br />

Carrel’s 1935 publication, Man, the Unknown,<br />

combined with his religious, or even mystical<br />

declarations, led him to speculate on the great problems<br />

of human destiny. Carrel theorised that mankind could<br />

reach perfection through selective reproduction <strong>and</strong> the<br />

leadership of an intellectual aristocracy. Through<br />

scientific enlightenment humanity would be free from<br />

disease, <strong>and</strong> achieve longevity <strong>and</strong> spiritual<br />

advancement. He proposed gas chambers as the way to<br />

eradicate unwanted elements in society. ‘Eugenics’,<br />

Carrel wrote in the last chapter of Man, the Unknown,<br />

‘is indispensable for the perpetuation of the strong. A<br />

great race must propagate its best elements’. <strong>The</strong> book,<br />

a worldwide best-seller translated into nineteen<br />

languages, brought Carrel international fame. Was it<br />

the realisation that life was much more complex than<br />

previously thought that led Carrel to mysticism? This<br />

may have been the case, but what was it that led him to<br />

eugenics? One can argue that the experience of<br />

developing partial life forms, which contradicted the<br />

Christian-humanist perception of the whole body, drove


him to engage with the occult. In short, the ontological<br />

questions thrown up by Carrel’s scientific experiments<br />

ironically seem to have led to his mystic <strong>and</strong> eugenic<br />

tendencies.<br />

However, rather than looking at tissue culture or<br />

partial life as a metaphor for the pure <strong>and</strong> perfected<br />

life, we would like to explore partial life (or semi-life) as<br />

a hybrid, dependent <strong>and</strong> imperfect entity. In the '<strong>The</strong><br />

Tissue Culture King', written in 1926, Julian Huxley<br />

reflects <strong>and</strong> articulates some of the anxieties<br />

surrounding early experiments in this field. ‘<strong>The</strong> Tissue<br />

Culture King’ is a story about a Western scientist,<br />

Hascombe, who is captured by an African tribe. In order<br />

to save his life, he employs his skills in the service of an<br />

African king. He decides to merge scientific principles<br />

<strong>and</strong> techniques with the religious tendencies of the<br />

tribe. Hascombe then employs tissue culture techniques<br />

to create ‘<strong>The</strong> Factory of Kingship or Majesty, <strong>and</strong> the<br />

Wellspring of Ancestral Immortality’. <strong>The</strong> idea is to<br />

culture parts of the king’s (or other ancestors’) bodies<br />

<strong>and</strong>, through that, increase the biomass of the king,<br />

thus enabling the people of the community to own parts<br />

of the king, <strong>and</strong> to physically nurture, care <strong>and</strong> worship<br />

them. Furthermore, this technique promises to<br />

‘increase the safety, if not of the king as an individual,<br />

at least the life which was in him, <strong>and</strong> I presumed that<br />

this would be equally satisfactory from a theological<br />

point of view.’ Hence, the fragment st<strong>and</strong>s for the whole<br />

in this story. Huxley considers the wide implications of<br />

the discipline of tissue culture <strong>and</strong> the associated<br />

epistemological revelations by looking at the option of<br />

mass production. He also considers the economic <strong>and</strong><br />

spiritual potential of the use <strong>and</strong> abuse of scientific<br />

knowledge <strong>and</strong> of applied technologies <strong>and</strong> social


sensitivities (see also Wilson, 2005).<br />

Plasticity: Cell Lines, Tissue Engineering <strong>and</strong> <strong>The</strong><br />

Technoscientific Body<br />

It was not until 1948 that a continuous line of cells,<br />

originating from one organism, was established: it was<br />

the strain-L mouse cell line, still widely used in<br />

laboratories. <strong>The</strong> strain-L was followed three years<br />

later by the first continuous human cell line -- HeLa<br />

cells. HeLa cells constitute an immortal cell line that<br />

was derived from cervical cancer cells taken from a<br />

black American woman, Henrietta Lacks, who died of<br />

cancer in 1951. <strong>The</strong> cells were propagated without<br />

Lacks’ knowledge or permission. <strong>The</strong> case reveals many<br />

social <strong>and</strong> political paradoxes resulting from<br />

developments in biotechnology -- such as that a person<br />

(just like any other animal) cannot, according to the<br />

law, own her own tissues; the commercial rights of one’s<br />

own tissues; <strong>and</strong> issues of race, class <strong>and</strong> gender, which<br />

are especially heightened when profit is at stake. <strong>The</strong><br />

realization that cells from complex organisms can not<br />

only be sustained alive outside of the body, but also<br />

grow, divide <strong>and</strong> function emerged in the 1910s, when<br />

Dr. Alexis Carrel began his experiments in a technique<br />

he termed ’tissue culture’. However, it took more than<br />

eighty years to realize that cells could be grown in three<br />

dimensions to form a functional tissue that had the<br />

potential to replace missing or failing body parts. This<br />

development came from the collaborative work of a<br />

surgeon, Dr. Joseph Vacanti, <strong>and</strong> a material scientist,<br />

Dr. Robert Langer. <strong>The</strong>y developed a system that uses<br />

specially designed degradable polymers that act as a<br />

scaffold for the developing tissue.


Maintaining <strong>and</strong> growing living fragments, the semilivings,<br />

involves the creation of a surrogate<br />

technoscientific body (or epi-body). This technoscientific<br />

body provides conditions that allow the cells to grow<br />

<strong>and</strong> proliferate. In the most basic terms, this includes<br />

providing the right temperature, nutrients <strong>and</strong> other<br />

substances <strong>and</strong>, in some cases, substrates that promote<br />

cell growth. <strong>The</strong> cultivated fragments are<br />

unquestionably alive, in that they are metabolising,<br />

growing <strong>and</strong> multiplying. <strong>The</strong>y experience at least some<br />

of the processes <strong>and</strong> functions that are needed for<br />

something to be ’alive’. In the last couple of decades,<br />

<strong>and</strong> only in some cases, the technoscientific body <strong>and</strong><br />

the semi-living have begun to form a cyborgian entity,<br />

whereby function <strong>and</strong> feedback make such an entity a<br />

responsive <strong>and</strong> effective unit. <strong>The</strong> growth of threedimensional<br />

’functional’ tissues is no longer confined to<br />

the biomedical world. As other aspects of regenerative<br />

medicine such as stem cell, therapeutic cloning <strong>and</strong> cell<br />

engineering are increasingly taking dominance over the<br />

field, technologies that where originally developed for<br />

the purpose of tissue engineering in the 1990s are now<br />

being used for non-clinical ends. Tissues <strong>and</strong> cells from<br />

complex organisms are being grown in large quantities<br />

for the production of biological substances; liver cells<br />

are being grown as toxicity sensors; different cells from<br />

different sources (bodies <strong>and</strong> organs) are being<br />

cultivated together in micro-fluidic chambers to make<br />

‘animals’ on chips as an alternative to animal <strong>and</strong><br />

human drug testing; in vitro meat is being seriously<br />

considered as an alternative to traditional meat<br />

production; <strong>and</strong> an increasing number of artists,<br />

designers <strong>and</strong> architects are working with living tissue<br />

as part of their practice.


With regard to the current research into the production<br />

of in vitro meat, the editors of this Living Book actually<br />

began exploring the possibility of growing meat without<br />

the need to slaughter animals already in 2000, as part<br />

of their residency at the Tissue Engineering & Organ<br />

Fabrication Laboratory at Harvard Medical School in<br />

2000. <strong>The</strong> first steak was grown from pre-natal sheep<br />

cells (skeletal muscle), harvested as part of the research<br />

into tissue engineering techniques in utero. <strong>The</strong> steak<br />

was grown from an animal that had not yet been born.<br />

However, one major complication arising from such a<br />

‘victimless meat endeavour’ as a manifestation of the<br />

techno-scientific project is that it may create an illusion<br />

of victimless existence. First, in order to grow in vitro<br />

meat, there is still the need for a serum, which is<br />

created by using animals’ blood plasma. Although<br />

research to find alternatives for this ingredient is being<br />

developed, there is no solution in the near sight <strong>and</strong><br />

animals (mainly calves or foetal bovines) are sacrificed<br />

for that ingredient. Second, we need to consider the<br />

total cost involved in running a laboratory, i.e., the<br />

fossil fuels burned, the green house gases produced, the<br />

water <strong>and</strong> trees consumed, the miles travelled <strong>and</strong> the<br />

waste created. Third, what we are witnessing here is a<br />

shift from ‘the red in tooth <strong>and</strong> claw’ nature to a<br />

mediated nature. In this process, victims are pushed<br />

farther away; they still exist, but are now much more<br />

implicit <strong>and</strong> inconspicuous.<br />

Different cells from different bodies (regardless of sex,<br />

race, age or animal species) can be co-cultured.<br />

Furthermore in some cases, cells fuse. Cell fusion is ‘the<br />

nondestructive merging of the contents of two cells by<br />

artificial means, resulting in a heterokaryon that will<br />

reproduce genetically alike, multinucleated progeny for


a few generations’.1 When an undifferentiated stem cell<br />

fuses with a mature differentiated cell, the resultant<br />

cell retains the mature cell phenotype.2 Cell fusion<br />

among different species <strong>and</strong> different families along the<br />

evolutionary tree has been carried out successfully<br />

since the 1970s. One example, the fusion of Xenopus<br />

<strong>and</strong> carrot cells, was discussed in 1978: Cultured<br />

Xenopus cells have been induced to fuse with carrot<br />

suspension cell protoplasts using PEG at high pH in the<br />

presence of high Ca2+. Ultrastructural observations<br />

confirm unambiguously that the fusion bodies seen by<br />

light microscopy are animal/plant cell heterokaryons.<br />

<strong>The</strong> cytoplasmic events occurring in these<br />

Xenopus/carrot fusion products during the first 48<br />

hours of culture provide evidence for their viability (see<br />

Davey et al., 1978). <strong>The</strong> phenomenon of cell fusion,<br />

besides its practical applications such as a method for<br />

passing on specific genes to specific chromosomes,<br />

compelled Oxford University Professor Henry Harris to<br />

write about his experience as a pioneer in cell fusion<br />

techniques (see Harris, 2005). Harris’ 2005 article<br />

opens with a somewhat romantic quote:<br />

<strong>The</strong>re is a tendency for living things to join up,<br />

establish linkages, live inside each other, return to<br />

earlier arrangements, get along, whenever possible.<br />

This is the way of the world. <strong>The</strong> new phenomenon of<br />

cell fusion, a laboratory trick on which much of today’s<br />

science of molecular genetics relies for its data, is the<br />

simplest <strong>and</strong> most spectacular symbol of the tendency.<br />

In a way, it is the most unbiologic of all phenomena,<br />

violating the most fundamental myths of the last<br />

century, for it denies the importance of specificity,<br />

integrity, <strong>and</strong> separateness in living things. Any cell –<br />

man, animal, fish, fowl, or insect – given the chance<br />

<strong>and</strong> under the right conditions, brought into contact<br />

with any other cell, however foreign, will fuse with it.


Cytoplasm will flow easily from one to the other, the<br />

nuclei will combine, <strong>and</strong> it will become, for a time<br />

anyway, a single cell with two complete, alien<br />

genomes, ready to dance, ready to multiply. It is a<br />

Chimera, a Griffon, a Sphinx, a Ganesha, a Peruvian<br />

God, a Ch'i-lin, an omen of good fortune, a wish for the<br />

world. (Thomas Lewis, cited in Harris, 2005)<br />

<strong>Semi</strong>-Living Art <strong>and</strong> Neolife<br />

One of the roles that art can play is that of offering<br />

scenarios for ‘worlds under construction’ <strong>and</strong> of<br />

subverting technologies for the purpose of creating<br />

contestable objects (see Dixon, 2009). This role of art<br />

makes the emergence of the semi-livings as evocative<br />

art ‘objects’ <strong>and</strong> the multi-level exploration of their use<br />

so relevant <strong>and</strong> important. <strong>The</strong> Tissue Culture & Art<br />

Project (TC&A), was set up by us (Oron Catts <strong>and</strong> Ionat<br />

Zurr) in 1996 to explore, develop <strong>and</strong> critique the use of<br />

tissue technologies for artistic ends. From the<br />

beginning, TC&A has been interested on a practical<br />

level in investigating human relationships with the<br />

different gradients of life through the construction <strong>and</strong><br />

growth of a new class of objects/beings -- that of the<br />

semi-living. <strong>The</strong> semi-living form parts of complex<br />

organisms which are sustained alive outside of the<br />

body, <strong>and</strong> which are coerced to grow in predetermined<br />

shapes. <strong>The</strong>se evocative objects are a tangible example<br />

that brings into question our deep-rooted perceptions of<br />

life, identity <strong>and</strong> selfhood, <strong>and</strong> the position of the<br />

human with regard to other living beings <strong>and</strong> the<br />

environment. We are interested in the new discourses<br />

<strong>and</strong> the new ethics, epistemology <strong>and</strong> ontology opened<br />

up by issues of partial life <strong>and</strong> by the contestable future<br />

scenarios these partial life forms are offering us. With<br />

this, we have relied on <strong>and</strong> developed some new ways of


growing tissue by using <strong>and</strong> subverting scientific tools<br />

<strong>and</strong> techniques from almost a hundred years ago to the<br />

present.<br />

As discussed briefly earlier, one of the more interesting<br />

interpretations, <strong>and</strong> definitely the most postanthropocentric<br />

perspective on the existence of the<br />

HeLa cell line, comes from a scientist, Leigh Van Valen.<br />

Van Valen controversially suggested to his peers that<br />

the HeLa cell line was an embodiment of a new<br />

taxonomical branch -- that it was a new species of its<br />

kind. Due to its ability to replicate indefinitely, <strong>and</strong> its<br />

non-human chromosome number, Leigh Van Valen<br />

described HeLa as an example of the contemporary<br />

creation of a new species, Helacyton gartleri. It was<br />

named after Stanley M. Gartler, whom Van Valen<br />

credits with discovering ‘the remarkable success of this<br />

species’. His argument for speciation depends on three<br />

points: • <strong>The</strong> chromosomal incompatibility of HeLa<br />

cells with humans, which makes them non-human. •<br />

<strong>The</strong>ir ecological niche, which may be technologically<br />

dependent, but we can assert that many species,<br />

including humans to a large extent, are by now<br />

technologically dependent. • <strong>The</strong>ir ability to persist <strong>and</strong><br />

exp<strong>and</strong> well beyond the intentions <strong>and</strong> imaginations of<br />

human cultivators.<br />

Scientific knowledge leads to shifts in the perception of<br />

life: life is becoming a raw material, while biology is<br />

turning into engineering. Whenever life <strong>and</strong> technology<br />

mix, odd things happen. Where does lab-grown <strong>and</strong><br />

engineered life fit in the human taxonomy? In tissue<br />

banks that provide cell lines, one starts to find all sorts<br />

of oddities: cells that have three different organisms as<br />

its origins, or fused cells of human <strong>and</strong> mouse origin.<br />

<strong>The</strong>se cells are only classified by catalogue numbers or


y very unusual names. This is what we can describe as<br />

neolife. More <strong>and</strong> more museums have started to collect<br />

fragments of life; frozen cells that represent the whole.<br />

Here, the technology of collection is converging with the<br />

technology of making strange. <strong>The</strong> old ways of<br />

privileging form (staffed idealised forms of animals) are<br />

been replaced with information <strong>and</strong> fragments on<br />

display. New life forms are entering collections, but the<br />

collection is not complete -- the ‘odd neolife’ is not part<br />

of our natural history collections, as the lab-grown, labmodified<br />

life forms are still absent from it. Our Odd<br />

Neolifism is an updated cabinet of curiosities. Museums<br />

have their own conventions with regard to displaying<br />

preserved life forms. In the Odd Neolifism display,<br />

ideas about a progressive complexity of species are<br />

questioned. At the far end of the display we have<br />

included the only living element -- cell tissue within a<br />

bioreactor (a surrogate, technological body). <strong>The</strong>se life<br />

forms are so abstracted from their source <strong>and</strong> yet they<br />

are growing. Perhaps it is time to realise that we need<br />

to find a place in our ecology for neolife.<br />

A pattern, even if somewhat blurry <strong>and</strong> ever changing,<br />

may be observed among the different examples of the<br />

semi-living. It is manifest in the desire to sense as well<br />

as make sense of a situation that is postanthropocentric<br />

<strong>and</strong> in the attempt to articulate the<br />

relation <strong>and</strong> interdependency of all living parts along<br />

the continuum of life <strong>and</strong> technology, through the<br />

intriguing <strong>and</strong> perplexing example of the in-between –<br />

the semi-living. This opens up new discourses about the<br />

different relationships we might form with these neolife<br />

forms, allowing us to shed new light on our perception<br />

of life. Such entities might eventually become<br />

fetishised, or even become our 'natural-ish' companions,<br />

thus invading <strong>and</strong> replacing our constructed <strong>and</strong>


manufactured environments with growing, moving,<br />

soft, moist, <strong>and</strong> care-needing things.<br />

Notes<br />

1 http://medicaldictionary.thefreedictionary.com/cell+fusion<br />

2<br />

http://www.medterms.com/script/main/art.asp?articleke<br />

y=32440 

<br />

References<br />

Davey, M. R., Clothier, R. H., Balls, M. & Cocking, E. E.<br />

(1978) 'An ultrastructural study of the fusion of<br />

cultured amphibian cells with higher plant protoplasts',<br />

Protoplasma, 96:1-2, 157-172.<br />

Dixon, D. P. (2009) 'Creating the semi-living: on<br />

politics, aesthetics <strong>and</strong> the more-than-human',<br />

Transactions of the Institute of British Geographers,<br />

Volume 34, Issue 4.<br />

Harris, H. (2005) 'Roots: Cell Fusion', BioEssays, 2:4,<br />

176-179. 

 W ilson , D . (2 0 0 5 ) 'Early Tissue Culture in<br />

Britain: the Interwar Years', Social History of Medicine<br />

(August) 18 (2), 225-243.


Articles<br />

<strong>The</strong> Historical Perspective on the <strong>Semi</strong>-<br />

Living<br />

Precursors of the <strong>Semi</strong>-Living<br />

St<strong>and</strong>ard of the World Cyphers Incubator Company,<br />

Buffalo N.Y., U.S.A. Annual catalogue, published 1896<br />

Poultry Growers' Guide for 1912, published by Buffalo,<br />

Cyphers Incubator Co.<br />

Dr Lawrence M. Gartner <strong>and</strong> Dr Carol B. Gartner<br />

<strong>The</strong> Care of Premature Infants: Historical Perspective<br />

<strong>The</strong> History of Tissue Culture<br />

Alexis Carrel<br />

On the Permanent Life of Tissues Outside of the Organism<br />

Alexis Carrel <strong>and</strong> Montrose T. Burrows<br />

Cultivation of Tissues In Vitro <strong>and</strong> Its Technique<br />

Alexis Carrel <strong>and</strong> Montrose T. Burrows<br />

An Addition to the Technique of the Cultivation of Tissues<br />

In Vitro<br />

Alexis Carrel<br />

Contributions to the Study of the Mechanism of the Growth<br />

of Connective Tissue<br />

J. A. Witkowski<br />

Alexis Carrel <strong>and</strong> the Mysticism of Tissue Culture<br />

Alexis Carrel<br />

Men, the Unknown


Julian Huxley<br />

<strong>The</strong> Tissue Culture King<br />

<strong>The</strong> Plasticity of Cell Lines<br />

About the ATCC-LGC St<strong>and</strong>ards Partnership, which<br />

facilitates the distribution of ATCC cultures <strong>and</strong><br />

bioproducts to life science researchers throughout Europe<br />

<strong>and</strong> India<br />

Stephen J. O'Brien<br />

Cell Culture Forensics<br />

Brendan P. Lucey, Walter A. Nelson-Rees <strong>and</strong> Grover M.<br />

Hutchins<br />

Henrietta Lacks, HeLa Cells, <strong>and</strong> Cell Culture<br />

Contamination<br />

<strong>The</strong> Technoscientific Body<br />

Mark J. Powers et al.<br />

A Microfabricated Array Bioreactor for Perfused 3D Liver<br />

Culture<br />

Jianzhong Xi, Jacob J. Schmidt <strong>and</strong> Carlo D. Montemagno<br />

Self-Assembled Microdevices Driven by Muscle<br />

Thomas Bol<strong>and</strong> et al.<br />

Cell <strong>and</strong> Organ Printing 2: Fusion of Cell Aggregates in<br />

Three-Dimensional Gels<br />

I. Datar <strong>and</strong> M. Betti<br />

Possibilities for an In Vitro Meat Production System<br />

P. D. Edelman et al.<br />

In Vitro Cultured Meat Production<br />

Cell Fusion


Cell Fusion<br />

Regenerative Medicine <strong>and</strong> Stem Cells<br />

Jeremy P. Brockes <strong>and</strong> Anoop Kumar<br />

Appendage Regeneration in Adult Vertebrates <strong>and</strong><br />

Implications for Regenerative Medicine<br />

Farhan Chowdhury et al.<br />

Soft Substrates Promote Homogeneous Self Renewal of<br />

Embryonic Stem Cells via Downregulating Cell-Matrix<br />

Tractions<br />

Hannah L<strong>and</strong>ecker<br />

Living Differently in Time: Plasticity, Temporality, <strong>and</strong><br />

Cellular Biotechnologies<br />

<strong>Semi</strong>-Living Art<br />

Oron Catts <strong>and</strong> Ionat Zurr<br />

Towards a New Class of Being –<strong>The</strong> Extended Body<br />

Oron Catts <strong>and</strong> Ionat Zurr<br />

Big Pigs, Small Wings: On Genohype <strong>and</strong> Artistic<br />

Autonomy<br />

Oron Catts, ed.<br />

<strong>The</strong> Aesthetics of Care<br />

Neolife<br />

<strong>The</strong> Tissue Culture <strong>and</strong> Art Project<br />

<strong>The</strong> Frozen Ark Project


Attributions<br />

St<strong>and</strong>ard of the World Cyphers Incubator Company<br />

Buffalo N.Y. U.S.A. Annual Catalogue published 1896.<br />

Link:<br />

http://www.slpowermuseum.com/equipment/cypher/cyp<br />

hersManual.pdf.<br />

Licence: In public domain. Made available via a link to<br />

the website of St. Lawrence Power <strong>and</strong> Equipment<br />

Museum.<br />

Poultry growers guide for 1912, published by Buffalo,<br />

Cyphers Incubator Co. Link:<br />

http://www.archive.org/details/poultrygrowersgu00cyph<br />

Licence: In public domain. Made available via a link to<br />

the Internet Archive.<br />

Dr Lawrence M. Gartner <strong>and</strong> Dr Carol B. Gartner, '<strong>The</strong><br />

Care of Premature Infants: Historical Perspective in<br />

Neonatal Intensive Care', NEONATAL INTENSIVE<br />

CARE - A HISTORY OF EXCELLENCE, A Symposium<br />

Commemorating Child Health Day Sponsored by the<br />

National Institute of Child Health <strong>and</strong> Human<br />

Development. Originally presented October 7, 1985,<br />

National Institutes of Health Bethesda, Maryl<strong>and</strong> NIH<br />

Publication No. 92-2786, October 1992. P.4. Link:<br />

http://www.neonatology.org/classics/nic.nih1985.pdf.<br />

Licence: U.S. DEPARTMENT OF HEALTH AND<br />

HUMAN SERVICES. Public Health Service, National<br />

Institutes of Health NIH Publication, made available<br />

via a link to http://www.neonatology.org.<br />

Carrell, A. (1912) 'On the permanent life of tissues<br />

outside of the organism', Journal of Experimental<br />

Medicine, vol. 15 no. 5 (May 1), <strong>The</strong> Rockefeller<br />

University Press, 516-528. Link:


http://jem.rupress.org/content/15/5/516.full.pdf. Licence:<br />

Ownership of copyright remains with Rockefeller<br />

University Press authors. Third parties may reuse our<br />

content for noncommercial purposes without specific<br />

permission as long as they provide proper attribution.<br />

Carrel, A. & Burrow, M. T. (1911) 'Cultivation of tissues<br />

in vitro <strong>and</strong> its technique', Journal of Experimental<br />

Medicine, 13 (3) (March 1): 387-396. Link<br />

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125263/<br />

pdf/387.pdf.<br />

Licence: Ownership of copyright remains with<br />

Rockefeller University Press authors. Third parties<br />

may reuse our content for noncommercial purposes<br />

without specific permission as long as they provide<br />

proper attribution. Available in PubMed Central c/o<br />

Rockefeller University Press. PMCID: PMC2125263.<br />

Carrel, A. & Burrow, M. T. (1911) 'An addition to the<br />

technique of the cultivation of tissues in vitro', Journal<br />

of Experimental Medicine, 14 (3) (September 1): 244-<br />

247. Link:<br />

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2124775/<br />

pdf/244.pdf. Licence: Ownership of copyright remains<br />

with Rockefeller University Press authors. Third<br />

parties may reuse our content for noncommercial<br />

purposes without specific permission as long as they<br />

provide proper attribution. Available in PubMed<br />

Central c/o Rockefeller University Press. PMCID:<br />

PMC2124775.<br />

Carrel, A. (1913) 'Contributions to the study of the<br />

mechanism of the growth of connective tissue', Journal<br />

of Experimental Medicine, 18 (3) (September 1): 287-<br />

298. Link:


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125069/<br />

pdf/287.pdf.<br />

Licence: Ownership of copyright remains with<br />

Rockefeller University Press authors. Third parties<br />

may reuse our content for noncommercial purposes<br />

without specific permission as long as they provide<br />

proper attribution. Available in PubMed Central c/o<br />

Rockefeller University Press. PMCID: PMC2125069.<br />

Witkowski, J. A. (1979) 'Alexis Carrel <strong>and</strong> the<br />

mysticism of tissue culture', Medical History, 23:279-<br />

296. Link:<br />

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082475/<br />

pdf/medhist00098-0025.pdf. Licence: Available via a<br />

link to PubMed Central, PMCID: PMC1082475.<br />

Articles from Medical History are provided there<br />

courtesy of <strong>The</strong> Wellcome Trust Centre for the History<br />

of Medicine at UCL.<br />

Carrel, A. (1935/1939) Men, the Unknown, HARPER &<br />

BROTHERS. Link:<br />

http://quantumfieldtheory.org/ALEXIS%20CARREL%2<br />

0Man%20the%20Unknown%201935.pdf.<br />

Licence: In public domain. Available here via a link to<br />

<strong>The</strong> Quantum Field <strong>The</strong>ory blog.<br />

Huxley, J. (1946) '<strong>The</strong> Tissue Culture King', in Great<br />

Science Fictions by Scientists, Groff Conklin Ed.,<br />

Collier Books NY pp.147-170 1946. Link:<br />

http://www.revolutionsf.com/fiction/tissue/index.html.<br />

Licence: In public domain. Available here via a link to<br />

Revolution SF.<br />

About the ATCC-LGC St<strong>and</strong>ards Partnership. Website<br />

link.


O'Brien, S. J. (2001) 'Cell culture forensics', Proceedings<br />

of the National Academy of Sciences of the United States<br />

of America, vol. 98, no. 14 (July 3), 7656–7658. Link:<br />

http://www.pnas.org/content/98/14/7656.full.pdf<br />

Licence: Available here via a link to PNAS Online.<br />

PNAS Online launched in January 1997 <strong>and</strong> now<br />

receives over 21 million hits per month. <strong>The</strong> site<br />

contains the full text, figures, tables, equations, <strong>and</strong><br />

references of all articles in PNAS dating back to 1990.<br />

Lucey, B. P., Nelson-Rees, W. A., & Hutchins, G. M.<br />

(2009) 'Henrietta Lacks, HeLa Cells, <strong>and</strong> Cell Culture<br />

Contamination', Archives of Pathology & Laboratory<br />

Medicine: September , Vol. 133, No. 9, 1463-1467. Link:<br />

http://www.archivesofpathology.org/doi/full/10.1043/154<br />

3-2165-133.9.1463. Licence: Copyright © 2011 College of<br />

American Pathologists. Available here via a link to the<br />

Archives of Pathology & Laboratory Medicine website,<br />

where this article is free to read.<br />

Powers, M. et al. (2002) A microfabricated array<br />

bioreactor for perfused 3D liver culture, Biotechnology<br />

<strong>and</strong> Bioengineering, volume 78, issue 3, 237-353. Link:<br />

http://www.ocf.berkeley.edu/~mctbl/BiotechBioeng2002<br />

_LiverChip.pdf Licence:<br />

Xi, J., Schmidt, J. J., & Montemagno, C. D. (2005) 'Selfassembled<br />

microdevices driven by muscle', 1, in Nature<br />

Materials 4, 180 - 184.’<br />

Link:<br />

http://www.nature.com/nmat/journal/v4/n2/full/nmat13<br />

08.html.<br />

Licence: Copyright: Nature Publishing Group. Made<br />

freely available on the Nature website <strong>and</strong> offered here<br />

via a link.


Bol<strong>and</strong>, T. et al. (2003), 'Cell <strong>and</strong> Organ Printing 2:<br />

Fusion of Cell Aggregates in Three-Dimensional Gels',<br />

<strong>The</strong> Anatomical Record Part A: Discoveries in<br />

Molecular, Cellular, <strong>and</strong> Evolutionary Biology, Volume<br />

272A, Issue 2, Link:<br />

http://onlinelibrary.wiley.com/doi/10.1002/ar.a.10059/pd<br />

f.<br />

Licence: © 2003 WILEY-LISS, INC. Made freely<br />

available on the Wiley Online website <strong>and</strong> offered here<br />

via a link.<br />

Datar, I. & Betti, M. (2010) 'Possibilities for an in vitro<br />

meat production system', Innovative Food Science <strong>and</strong><br />

Emerging Technologies, 11, 13–22. Link:<br />

http://www.newharvest.org/img/files/datar_<strong>and</strong>_betti.pdf.<br />

Licence: © 2009 Elsevier Ltd. Made available here via a<br />

link to the New Harvest website.<br />

Edelman, P. D., McFarl<strong>and</strong>, D. C., Mironov, V. A., &<br />

Matheny, J. G. (2005) 'In vitro cultured meat<br />

production', Tissue Engineering, May/June, 11(5-6):<br />

659-662.<br />

Link: http://www.new-harvest.org/img/files/Invitro.pdf.<br />

Licence: Author's manuscript. Made available here via<br />

a link to the New Harvest website.<br />

Cell Fusion definition, link to <strong>The</strong> Free Dictionary by<br />

Farlex. Link: http://medicaldictionary.thefreedictionary.com/cell+fusion<br />

Brockes, J. P. & Kumar, A. (2005) 'Appendage<br />

Regeneration in Adult Vertebrates <strong>and</strong> Implications for<br />

Regenerative Medicine', Science 23 December, Vol. 310<br />

no. 5756, 1919-1923. Link:<br />

http://www.sciencemag.org/content/310/5756/1919.full



Licence: DOI: 10.1126/science.1115200. Freely available<br />

on the Science website <strong>and</strong> offered here via a link.<br />

Chowdhury, F. et al. (2010) 'Soft Substrates Promote<br />

Homogeneous Self Renewal of Embryonic Stem Cells<br />

via Downregulating Cell-Matrix Tractions', PLoS One,<br />

5(12): e15655. doi:10.1371/journal.pone.0015655. Link:<br />

http://www.plosone.org/article/info%3Adoi%2F10.1371%<br />

2Fjournal.pone.0015655.<br />

Licence: © 2010 Chowdhury et al. This is an openaccess<br />

article distributed under the terms of the<br />

Creative Commons Attribution License, which permits<br />

unrestricted use, distribution, <strong>and</strong> reproduction in any<br />

medium, provided the original author <strong>and</strong> source are<br />

credited.<br />

L<strong>and</strong>ecker, H. (2005) 'Living Differently in Time:<br />

Plasticity, Temporality, <strong>and</strong> Cellular Biotechnologies',<br />

Culture Machine, Vol 7. Link:<br />

http://www.culturemachine.net/index.php/cm/article/vie<br />

wArticle/26/33%3E.<br />

Licence: © L<strong>and</strong>ecker. Culture Machine is an openaccess<br />

journal.<br />

Catts, O. & Zurr, I. (2006) 'Towards a new class of being<br />

–<strong>The</strong> Extended Body', Artnodes, Issue 6, November.<br />

Link:<br />

http://www.uoc.edu/artnodes/6/dt/eng/catts_zurr.pdf
 Li<br />

cence: This work is subject to a Creative Commons<br />

Attribution-Noncommercial-NoDerivativeWorks 2.5<br />

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Catts, O. & Zurr, I. (2005), 'Big Pigs, Small Wings: On<br />

Genohype <strong>and</strong> Artistic Autonomy', Culture Machine,<br />

Vol 7. Link:<br />

http://www.culturemachine.net/index.php/cm/article/vie<br />

w/30/37.<br />

Licence: © Catts & Zurr. Culture Machine is an openaccess<br />

journal.<br />

Catts, O. 'Aesthetics of Care', Ed. ISBN: 1 74052 080 7.<br />

Link:<br />

http://www.tca.uwa.edu.au/publication/THE_AESTHET<br />

ICS_OF_CARE.pdf.<br />

Licence: © Catts. <strong>The</strong> Aesthetics of Care is published by<br />

SymbioticA, School of Anatomy <strong>and</strong> Human Biology,<br />

University of Western Australia, 35 Crawley Avenue,<br />

Nedl<strong>and</strong>s 6009. Western Australia. August 2002.<br />

www.symbiotica.uwa.edu.au

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