2 - BACTERIOWEB
2 - BACTERIOWEB
2 - BACTERIOWEB
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First description<br />
Antibiotic efflux<br />
60’: E. coli strains resistant to nalidixic acid (K. Arima)<br />
80’: Tet determinants (S. Levy)<br />
Since early 90’<br />
Several hundreds of characterized or putative efflux systems<br />
reported in the literature…<br />
Definition of efflux systems<br />
Transmembrane proteins able to actively transport diverse<br />
substrate molecules from the cell interior to the external medium<br />
Pumps : functional export systems<br />
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