2 - BACTERIOWEB
2 - BACTERIOWEB 2 - BACTERIOWEB
Main resistance mechanisms to drugs Inactivation Modification Cleaning Protection ANTIBIOTIC TARGET Substitution Amplification Efflux Impermeability Reduced affinity - mutations - recombinaisons - enzymatic modification 4
Drug inactivation Target alteration Decreased mb permeability Active efflux Drug resistance mechanisms +++ +++ + + ß-lactams +++ + + + Aminoglycosides Quinolones +/- +++ + + +/- +++ + + Macrolides +/- ++ + +++ 5 Tetracyclines Tetracyclines
- Page 1 and 2: Role of the Efflux Pumps in Antimic
- Page 3: Cell wall Bacterial targets for ant
- Page 7 and 8: Intracellular accumulation Drug acc
- Page 9 and 10: 9 Other bacterial species with know
- Page 11 and 12: Structure of bacterial efflux syste
- Page 13 and 14: PMF secondary transporters Major F
- Page 15 and 16: Efflux-based resistance in Staphylo
- Page 17 and 18: System NorA in S. aureus Antibiotic
- Page 19 and 20: Combination of mechanisms in S. aur
- Page 21 and 22: PmrA-mediated resistance in S. pneu
- Page 23 and 24: Other Gram positives Species System
- Page 25 and 26: 25 Efflux pumps coded by mobile gen
- Page 27 and 28: Efflux pumps of the RND family Bact
- Page 29 and 30: System AcrAB-TolC in E. coli Antibi
- Page 31 and 32: Induction of acrAB-tolC expression
- Page 33 and 34: RND efflux systems in P. aeruginosa
- Page 35 and 36: Acquired resistance in P. aeruginos
- Page 37 and 38: MexXY-mediated adaptive resistance
- Page 39 and 40: Therapeutic implications of efflux
- Page 41: Efflux inhibitors Phenyl-Arginyl ß
Drug inactivation<br />
Target alteration<br />
Decreased mb permeability<br />
Active efflux<br />
Drug resistance mechanisms<br />
+++<br />
+++<br />
+<br />
+<br />
ß-lactams<br />
+++<br />
+<br />
+<br />
+<br />
Aminoglycosides<br />
Quinolones<br />
+/-<br />
+++<br />
+<br />
+<br />
+/-<br />
+++<br />
+<br />
+<br />
Macrolides<br />
+/-<br />
++<br />
+<br />
+++<br />
5<br />
Tetracyclines<br />
Tetracyclines
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