2 - BACTERIOWEB

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Main resistance mechanisms to drugs Inactivation Modification Cleaning Protection ANTIBIOTIC TARGET Substitution Amplification Efflux Impermeability Reduced affinity - mutations - recombinaisons - enzymatic modification 4
Drug inactivation Target alteration Decreased mb permeability Active efflux Drug resistance mechanisms +++ +++ + + ß-lactams +++ + + + Aminoglycosides Quinolones +/- +++ + + +/- +++ + + Macrolides +/- ++ + +++ 5 Tetracyclines Tetracyclines
Page 1 and 2: Role of the Efflux Pumps in Antimic
Page 3: Cell wall Bacterial targets for ant
Page 7 and 8: Intracellular accumulation Drug acc
Page 9 and 10: 9 Other bacterial species with know
Page 11 and 12: Structure of bacterial efflux syste
Page 13 and 14: PMF secondary transporters Major F
Page 15 and 16: Efflux-based resistance in Staphylo
Page 17 and 18: System NorA in S. aureus Antibiotic
Page 19 and 20: Combination of mechanisms in S. aur
Page 21 and 22: PmrA-mediated resistance in S. pneu
Page 23 and 24: Other Gram positives Species System
Page 25 and 26: 25 Efflux pumps coded by mobile gen
Page 27 and 28: Efflux pumps of the RND family Bact
Page 29 and 30: System AcrAB-TolC in E. coli Antibi
Page 31 and 32: Induction of acrAB-tolC expression
Page 33 and 34: RND efflux systems in P. aeruginosa
Page 35 and 36: Acquired resistance in P. aeruginos
Page 37 and 38: MexXY-mediated adaptive resistance
Page 39 and 40: Therapeutic implications of efflux
Page 41: Efflux inhibitors Phenyl-Arginyl ß

2 - BACTERIOWEB

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