2 - BACTERIOWEB
2 - BACTERIOWEB
2 - BACTERIOWEB
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Therapeutic implications of efflux systems<br />
Resistance levels conferred by intrinsic pumps<br />
– Low to moderate drug resistance (MIC x 2 - 16)<br />
– Clinical significance<br />
♦ Lack of clinical data !<br />
♦ Poor response to treatment when the concentrations of<br />
antibiotics are low at the infection site (insufficient dosage,<br />
inappropriate drug, abcess...)<br />
♦ Increased emergence of target mutants ?<br />
Emergence of efflux mutants under treatment<br />
– Cross resistance to structurally unrelated molecules<br />
– Role of fluoroquinolones<br />
39
Change language