2 - BACTERIOWEB

More documents

Recommendations

Info

Genetic events leading to increased efflux IS mdr mutations mexR mexZ PA3721 nalC - - nalB - agrZ PA3720 PA3719 _ - mexA mexB oprM + mexX mexY PA5471 _ PA3574 nalD MexXY MexAB-OprM agrW C. Vogne et al. Antimicrob. Agents Chemother. 2004, 48: 1676 C. Llanes et al. Antimicrob. Agents Chemother. 2004, 48: 1797
MexXY-mediated adaptive resistance to AGs MIC (mg / L) 50 _ _ 40 _ 30 _ 20 _ 10 _ Stain ATCC 27853 exposed to 1 MIC amikacin for 2h every 8h (Karlowsky 1994) MIC of amikacin; Bacterial killing in log10 _ _ _ _ _ 2.5 2 1.5 1 0.5 Inoculum (log10 CFU) D. Hocquet et al. Antimicrob. Agents Chemother. 2003, 47: 1371
Page 1 and 2: Role of the Efflux Pumps in Antimic
Page 3 and 4: Cell wall Bacterial targets for ant
Page 5 and 6: Drug inactivation Target alteration
Page 7 and 8: Intracellular accumulation Drug acc
Page 9 and 10: 9 Other bacterial species with know
Page 11 and 12: Structure of bacterial efflux syste
Page 13 and 14: PMF secondary transporters Major F
Page 15 and 16: Efflux-based resistance in Staphylo
Page 17 and 18: System NorA in S. aureus Antibiotic
Page 19 and 20: Combination of mechanisms in S. aur
Page 21 and 22: PmrA-mediated resistance in S. pneu
Page 23 and 24: Other Gram positives Species System
Page 25 and 26: 25 Efflux pumps coded by mobile gen
Page 27 and 28: Efflux pumps of the RND family Bact
Page 29 and 30: System AcrAB-TolC in E. coli Antibi
Page 31 and 32: Induction of acrAB-tolC expression
Page 33 and 34: RND efflux systems in P. aeruginosa
Page 35: Acquired resistance in P. aeruginos
Page 39 and 40: Therapeutic implications of efflux
Page 41: Efflux inhibitors Phenyl-Arginyl ß

2 - BACTERIOWEB

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?