2 - BACTERIOWEB
2 - BACTERIOWEB 2 - BACTERIOWEB
Contribution to intrinsic resistance in P. aeruginosa Antibiotcs Wild type MexAB/M - MexXY/M - Norfloxacin 0.125 - 1 0.05 - 0.25 - Ciprofloxacin 0.03 - 0.25 0.012 - 0.03 - Carbenicillin 12.5 - 64 0.4 - 1 - Ceftazidime 0.4 - 2 0.2 - 0.4 - Cefepime 0.8 - 2 0.1 - 0.5 - Meropenem 0.2 - 0.5 0.1 - 0.2 - Tetracycline 6.25 - 16 2 2 - 4 Chloramphenicol 12.5 - 32 0.8 - 2 - Erythromycin 256 64 - 128 32 - 64 Tobramycin 0.5 - 0.125 Amikacin 2 - 0.5 CMI x 2-64 CMI x 2-8 34 (CMI mg/l)
Acquired resistance in P. aeruginosa Antibiotics Wild type MexAB/M MexCD/J MexEF/N MexXY/M Carbenicillin 8 - 32 64 - 256 Aztreonam 2 - 4 12.5 - 32 Ceftazidime 0.4 - 2 1.6 - 8 Cefepime 1 3 - 4 12.5 8 Cefpirom 1 - 2 4 - 8 8 - 16 Imipenem 0.8 - 1 6.25 - 8 Meropenem 0.2 - 0.5 0.8 - 2 Ciprofloxacin 0.03 - 0.125 0.4 - 1 0.8 - 1.6 0.8 - 1.6 0.5 - 1 Amikacin 2 4 - 16 Tobramycin 0.25 - 0.5 1 - 2 35 (CMI mg/l)
- Page 1 and 2: Role of the Efflux Pumps in Antimic
- Page 3 and 4: Cell wall Bacterial targets for ant
- Page 5 and 6: Drug inactivation Target alteration
- Page 7 and 8: Intracellular accumulation Drug acc
- Page 9 and 10: 9 Other bacterial species with know
- Page 11 and 12: Structure of bacterial efflux syste
- Page 13 and 14: PMF secondary transporters Major F
- Page 15 and 16: Efflux-based resistance in Staphylo
- Page 17 and 18: System NorA in S. aureus Antibiotic
- Page 19 and 20: Combination of mechanisms in S. aur
- Page 21 and 22: PmrA-mediated resistance in S. pneu
- Page 23 and 24: Other Gram positives Species System
- Page 25 and 26: 25 Efflux pumps coded by mobile gen
- Page 27 and 28: Efflux pumps of the RND family Bact
- Page 29 and 30: System AcrAB-TolC in E. coli Antibi
- Page 31 and 32: Induction of acrAB-tolC expression
- Page 33: RND efflux systems in P. aeruginosa
- Page 37 and 38: MexXY-mediated adaptive resistance
- Page 39 and 40: Therapeutic implications of efflux
- Page 41: Efflux inhibitors Phenyl-Arginyl ß
Acquired resistance in P. aeruginosa<br />
Antibiotics Wild type MexAB/M MexCD/J MexEF/N MexXY/M<br />
Carbenicillin 8 - 32 64 - 256<br />
Aztreonam 2 - 4 12.5 - 32<br />
Ceftazidime 0.4 - 2 1.6 - 8<br />
Cefepime 1 3 - 4 12.5 8<br />
Cefpirom 1 - 2 4 - 8 8 - 16<br />
Imipenem 0.8 - 1 6.25 - 8<br />
Meropenem 0.2 - 0.5 0.8 - 2<br />
Ciprofloxacin 0.03 - 0.125 0.4 - 1 0.8 - 1.6 0.8 - 1.6 0.5 - 1<br />
Amikacin 2 4 - 16<br />
Tobramycin 0.25 - 0.5 1 - 2<br />
35<br />
(CMI mg/l)
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