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2 - BACTERIOWEB

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Efflux/target double mutants of E. coli<br />

Genotype/Phenotype Oflo Cipro<br />

wild type AG100 0.03 ≤0.015<br />

AcrAB ++ 0.125 0.06<br />

gyrA (Asp87->Gly) 0.25 0.25<br />

gyrA (Asp87->Gly; Ser83->Leu) 4 2<br />

gyrA (Asp87->Gly), AcrAB ++ 8 4<br />

gyrA (Asp87->Gly), AcrAB - 0.06 0.03<br />

Oethinger et al. Antimicrob. Agents Chemother. 2000, 44: 10-13<br />

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