2 - BACTERIOWEB
2 - BACTERIOWEB 2 - BACTERIOWEB
28 Overexpression of acrAB and mtrCDE operons E. coli N. gonorrhoeae acrR mtrR - - acrA + + MarA acrB MtrA mtrC mtrD mtrE _ (MppA) MarR _ SoxS SoxR mutations mdr
System AcrAB-TolC in E. coli Antibiotics wild type AcrAB ++ AcrAB - Nalidixic acid 4 - 6 8.5 - 32 0.6 Norfloxacin 0.025 - 0.1 0.3 - 1.25 nd Ofloxacin 0.06 - 0.07 0.25 - 0.3 nd Ciprofloxacin 0.02 0.15 nd Ampicillin 2 - 4 5 - 6 0.6 - 2 Erythromycin 128 - 256 > 512 < 2 - 8 Tetracycline 1.25 - 3 5 - 16 0.25 - 0.3 Chloramphenicol 4 - 7.5 10 - 28 0.6 contribution to intrinsic resistance : CMI x 2-64 acquired resistance : CMI x 2-12 29 (CMI mg/l)
- Page 1 and 2: Role of the Efflux Pumps in Antimic
- Page 3 and 4: Cell wall Bacterial targets for ant
- Page 5 and 6: Drug inactivation Target alteration
- Page 7 and 8: Intracellular accumulation Drug acc
- Page 9 and 10: 9 Other bacterial species with know
- Page 11 and 12: Structure of bacterial efflux syste
- Page 13 and 14: PMF secondary transporters Major F
- Page 15 and 16: Efflux-based resistance in Staphylo
- Page 17 and 18: System NorA in S. aureus Antibiotic
- Page 19 and 20: Combination of mechanisms in S. aur
- Page 21 and 22: PmrA-mediated resistance in S. pneu
- Page 23 and 24: Other Gram positives Species System
- Page 25 and 26: 25 Efflux pumps coded by mobile gen
- Page 27: Efflux pumps of the RND family Bact
- Page 31 and 32: Induction of acrAB-tolC expression
- Page 33 and 34: RND efflux systems in P. aeruginosa
- Page 35 and 36: Acquired resistance in P. aeruginos
- Page 37 and 38: MexXY-mediated adaptive resistance
- Page 39 and 40: Therapeutic implications of efflux
- Page 41: Efflux inhibitors Phenyl-Arginyl ß
System AcrAB-TolC in E. coli<br />
Antibiotics wild type AcrAB ++ AcrAB -<br />
Nalidixic acid 4 - 6 8.5 - 32 0.6<br />
Norfloxacin 0.025 - 0.1 0.3 - 1.25 nd<br />
Ofloxacin 0.06 - 0.07 0.25 - 0.3 nd<br />
Ciprofloxacin 0.02 0.15 nd<br />
Ampicillin 2 - 4 5 - 6 0.6 - 2<br />
Erythromycin 128 - 256 > 512 < 2 - 8<br />
Tetracycline 1.25 - 3 5 - 16 0.25 - 0.3<br />
Chloramphenicol 4 - 7.5 10 - 28 0.6<br />
contribution to intrinsic resistance : CMI x 2-64<br />
acquired resistance : CMI x 2-12<br />
29<br />
(CMI mg/l)
Change language