2 - BACTERIOWEB
2 - BACTERIOWEB
2 - BACTERIOWEB
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Efflux pumps of the RND family<br />
Bacteria System Substrates<br />
E. coli AcrAB-TolC 1 Fq, ß-lactams 3 , Tc, Cmp, Nov, Ery, Fus, Rif…<br />
E. coli AcrEF-TolC 2 Fq, ß-lactams 3 , Tc, Cmp, Nov, Ery, Fus, Rif…<br />
E. coli AcrD 2 -AcrA-TolC AGs, Ery, PolyB<br />
E. coli CusAB-? 2 Fos<br />
E. coli MdtABC-TolC 2 Fq<br />
E. coli MdtEF-TolC 2 Ery<br />
P. aeruginosa MexAB-OprM 1 Fq, ß-lactams 1 , Tc, Cmp, Nov, Ery, Fus, Tm...<br />
N. gonorrhoeae MtrCDE 1 Tc, Cmp, ß-lactams 1 , Ery, Fus, Rif...<br />
Fq: (fluoro)quinolones; Tc: tetracycline; Cmp: chloramphenicol; Nov: novobiocin; Ery: erythromycin; Fus:<br />
fusidic acid; Rif: rifampicin; AGs: aminoglycosides; PolyB: polymyxin B; Fos: fosfomycin; Tmp: trimethoprim;<br />
3 rd GC: cefepime, cefpirome. 1 expressed constitutively in wild type cells, 2 inducible expression, 3 except imipenem.<br />
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