2 - BACTERIOWEB
2 - BACTERIOWEB 2 - BACTERIOWEB
Chromosomal genes Efflux systems in E. coli – 37 putative drug transporters: 19 MFS, 3 SMR, 7 RND, 7 ABC, 1 MATE – 20 pumps are able to transport toxic/antibiotic molecules – 15-17 pumps may provide with some resistance to antibiotics when overproduced from cloned genes (Nishino K et al. J. Bacteriol. 2001) – Most of these intrinsic systems are not expressed in standard laboratory growth conditions – Spontaneous mutations may result in stable overproduction of a single pump and resistance Foreign genes – Genes carried by mobile elements (plasmids, transposons) 24
25 Efflux pumps coded by mobile genetic elements Species System Family Substrates E. coli TetA/B/E MFS Tc, Min Tig E. coli CmlA MFS Cmp E. coli Flo MFS Cmp, Flo E. coli OqxAB-TolC RND Olaquindox, Cmp Tc: tetracycline; Min: minocycline; Cmp: chloramphenicol; Flo: florfenicol ; Tig: tigecycline
- Page 1 and 2: Role of the Efflux Pumps in Antimic
- Page 3 and 4: Cell wall Bacterial targets for ant
- Page 5 and 6: Drug inactivation Target alteration
- Page 7 and 8: Intracellular accumulation Drug acc
- Page 9 and 10: 9 Other bacterial species with know
- Page 11 and 12: Structure of bacterial efflux syste
- Page 13 and 14: PMF secondary transporters Major F
- Page 15 and 16: Efflux-based resistance in Staphylo
- Page 17 and 18: System NorA in S. aureus Antibiotic
- Page 19 and 20: Combination of mechanisms in S. aur
- Page 21 and 22: PmrA-mediated resistance in S. pneu
- Page 23: Other Gram positives Species System
- Page 27 and 28: Efflux pumps of the RND family Bact
- Page 29 and 30: System AcrAB-TolC in E. coli Antibi
- Page 31 and 32: Induction of acrAB-tolC expression
- Page 33 and 34: RND efflux systems in P. aeruginosa
- Page 35 and 36: Acquired resistance in P. aeruginos
- Page 37 and 38: MexXY-mediated adaptive resistance
- Page 39 and 40: Therapeutic implications of efflux
- Page 41: Efflux inhibitors Phenyl-Arginyl ß
25<br />
Efflux pumps coded by mobile genetic elements<br />
Species System Family Substrates<br />
E. coli TetA/B/E MFS Tc, Min Tig<br />
E. coli CmlA MFS Cmp<br />
E. coli Flo MFS Cmp, Flo<br />
E. coli OqxAB-TolC RND Olaquindox, Cmp<br />
Tc: tetracycline; Min: minocycline; Cmp: chloramphenicol; Flo: florfenicol ; Tig: tigecycline
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