2 - BACTERIOWEB
2 - BACTERIOWEB 2 - BACTERIOWEB
Expression System NorA in S. aureus – Constitutive or slightly inducible by FQs in wild-type strains – Increased by mutations in the promoter region of norA or in other loci Substrates – Identical to those of pump Bmr in Bacillus subtilis – Specificity related to C-7 residue and hydrophobicity of C-8 residue Inhibitors – CCCP, nigericin, nigericin, reserpin, reserpin, verapamil, verapamil, omprazole, omprazole lanzoprazole 16
System NorA in S. aureus Antibiotics Wild-type NorA+++ NorA- Nalidixic acid 25 - 125 100 - >1000 nd Norfloxacin 0.8 - 1.6 50 - 80 0.2 - 0.3 Ciprofloxacin 0.25 - 0.7 6 0.1 - 0.2 Ofloxacin 0.2 - 0.5 1.5 - 3 0.4 Pefloxacin 0.5 12.5 nd Sparfloxacin 0.1 0.2 0.1 Cetrimide 0.4 6.5 nd Benzalkonium 1 3 nd Ethidium bromide 5 - 6.5 25 0.5 17 (CMI µg/mL
- Page 1 and 2: Role of the Efflux Pumps in Antimic
- Page 3 and 4: Cell wall Bacterial targets for ant
- Page 5 and 6: Drug inactivation Target alteration
- Page 7 and 8: Intracellular accumulation Drug acc
- Page 9 and 10: 9 Other bacterial species with know
- Page 11 and 12: Structure of bacterial efflux syste
- Page 13 and 14: PMF secondary transporters Major F
- Page 15: Efflux-based resistance in Staphylo
- Page 19 and 20: Combination of mechanisms in S. aur
- Page 21 and 22: PmrA-mediated resistance in S. pneu
- Page 23 and 24: Other Gram positives Species System
- Page 25 and 26: 25 Efflux pumps coded by mobile gen
- Page 27 and 28: Efflux pumps of the RND family Bact
- Page 29 and 30: System AcrAB-TolC in E. coli Antibi
- Page 31 and 32: Induction of acrAB-tolC expression
- Page 33 and 34: RND efflux systems in P. aeruginosa
- Page 35 and 36: Acquired resistance in P. aeruginos
- Page 37 and 38: MexXY-mediated adaptive resistance
- Page 39 and 40: Therapeutic implications of efflux
- Page 41: Efflux inhibitors Phenyl-Arginyl ß
System NorA in S. aureus<br />
Antibiotics Wild-type NorA+++ NorA-<br />
Nalidixic acid 25 - 125 100 - >1000 nd<br />
Norfloxacin 0.8 - 1.6 50 - 80 0.2 - 0.3<br />
Ciprofloxacin 0.25 - 0.7 6 0.1 - 0.2<br />
Ofloxacin 0.2 - 0.5 1.5 - 3 0.4<br />
Pefloxacin 0.5 12.5 nd<br />
Sparfloxacin 0.1 0.2 0.1<br />
Cetrimide 0.4 6.5 nd<br />
Benzalkonium 1 3 nd<br />
Ethidium bromide 5 - 6.5 25 0.5<br />
17<br />
(CMI µg/mL
Change language