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2 - BACTERIOWEB

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Expression<br />

System NorA in S. aureus<br />

– Constitutive or slightly inducible by FQs in wild-type strains<br />

– Increased by mutations in the promoter region of norA or in<br />

other loci<br />

Substrates<br />

– Identical to those of pump Bmr in Bacillus subtilis<br />

– Specificity related to C-7 residue and hydrophobicity of C-8<br />

residue<br />

Inhibitors<br />

– CCCP, nigericin, nigericin,<br />

reserpin, reserpin,<br />

verapamil, verapamil,<br />

omprazole, omprazole<br />

lanzoprazole<br />

16

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