2 - BACTERIOWEB
2 - BACTERIOWEB 2 - BACTERIOWEB
ABC transporters Energy sources – ATP binding cassette pumps – Hydrolysis of ATP into ADP + Pi – Mostly in Gram positive species Secondary transporters – H + /substrate antiporters (proton motive force) – Na + /substrate antiporters 12
PMF secondary transporters Major Facilitator Superfamily (MFS) – Drug efflux ♦ 12 TMS transporters ♦ 14 TMS transporters – Active uptake/export ♦ sugars... ♦ amino acids, secondary metabolites... Small Multidrug Resistance Family (SMR) ♦ 4 TMS transporters Resistance/Nodulation Cell Division Family (RND) ♦ 12 TMS transporters Multi Antimicrobial Extrusion Family (MATE) ♦ 12 TMS transporters 13
- Page 1 and 2: Role of the Efflux Pumps in Antimic
- Page 3 and 4: Cell wall Bacterial targets for ant
- Page 5 and 6: Drug inactivation Target alteration
- Page 7 and 8: Intracellular accumulation Drug acc
- Page 9 and 10: 9 Other bacterial species with know
- Page 11: Structure of bacterial efflux syste
- Page 15 and 16: Efflux-based resistance in Staphylo
- Page 17 and 18: System NorA in S. aureus Antibiotic
- Page 19 and 20: Combination of mechanisms in S. aur
- Page 21 and 22: PmrA-mediated resistance in S. pneu
- Page 23 and 24: Other Gram positives Species System
- Page 25 and 26: 25 Efflux pumps coded by mobile gen
- Page 27 and 28: Efflux pumps of the RND family Bact
- Page 29 and 30: System AcrAB-TolC in E. coli Antibi
- Page 31 and 32: Induction of acrAB-tolC expression
- Page 33 and 34: RND efflux systems in P. aeruginosa
- Page 35 and 36: Acquired resistance in P. aeruginos
- Page 37 and 38: MexXY-mediated adaptive resistance
- Page 39 and 40: Therapeutic implications of efflux
- Page 41: Efflux inhibitors Phenyl-Arginyl ß
ABC transporters<br />
Energy sources<br />
– ATP binding cassette pumps<br />
– Hydrolysis of ATP into ADP + Pi<br />
– Mostly in Gram positive species<br />
Secondary transporters<br />
– H + /substrate antiporters (proton motive force)<br />
– Na + /substrate antiporters<br />
12
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