2 - BACTERIOWEB
2 - BACTERIOWEB
2 - BACTERIOWEB
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Structure of bacterial efflux systems<br />
One component systems<br />
– Mostly in Gram positive species (except Tet...)<br />
– A single transporter protein in the cytoplasmic membrane<br />
– Determines the substrate specificity and resistance<br />
Three component (tripartite) systems<br />
– Exclusively in Gram negative species (GNB)<br />
♦ A transporter protein<br />
♦ A periplasmic adaptor lipoprotein<br />
♦ A outer membrane channel protein<br />
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