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Changing MIC Breakpoints: Do Mechanisms Count

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Clinical Studies<br />

• No randomized controlled trials have ever<br />

been performed that evaluated the use of<br />

various comparator antibiotics in treatment of<br />

serious infections due to ESBL-producing<br />

organisms<br />

• It is unlikely that such studies will ever be<br />

performed<br />

• Existing data comes only from retrospective<br />

studies<br />

9

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