Changing MIC Breakpoints: Do Mechanisms Count

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Something to Think About • <strong>Breakpoints</strong> can vary by infection type (e.g., cystitis vs. sepsis vs. meningitis, etc.). • <strong>Breakpoints</strong> can vary by the method of antibiotic administration (e.g., oral vs. IV administration) or dosage given (customary vs. highest dose). • The FDA and CLSI breakpoints are based only on the drug level achieved in blood using the customary dose 38
Something to Think About • In fact, the antibiotic reports issued by the laboratory are most often not for infections occurring in the blood (LUMC Feb ’11 87/813) • Drug concentrations at sites of infection outside blood stream may be higher or lower than those in blood, rendering the breakpoint less useful in these sites. 39
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Page 3 and 4: • The major issue is whether the
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Page 42 and 43: Personalized Antibiotic Report •
Page 44 and 45: Personalized Antibiotic Report •
Page 46: Are the New CLSI Breakpoints the Co

Changing MIC Breakpoints: Do Mechanisms Count

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