Changing MIC Breakpoints: Do Mechanisms Count
Changing MIC Breakpoints: Do Mechanisms Count
Changing MIC Breakpoints: Do Mechanisms Count
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Something to Think About<br />
• <strong>Breakpoints</strong> can vary by infection type (e.g.,<br />
cystitis vs. sepsis vs. meningitis, etc.).<br />
• <strong>Breakpoints</strong> can vary by the method of antibiotic<br />
administration (e.g., oral vs. IV administration)<br />
or dosage given (customary vs. highest dose).<br />
• The FDA and CLSI breakpoints are based only<br />
on the drug level achieved in blood using the<br />
customary dose<br />
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