Changing MIC Breakpoints: Do Mechanisms Count

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Enterobacteriaceae – Evaluated but NOT Revised <strong>Breakpoints</strong> Agent CLSI M100-S20 (2010) Cefuroxime (parenteral) Susc Int Res 8 16 32 Cefepime 8 16 32 Cefotetan 16 32 64 Cefoxitin 8 16 32 CLSI M100-S20. Table 2A 28
Cephaloporin <strong>Breakpoints</strong> Following Recent EUCAST and CLSI Revisions Group Cefuroxime S /R> Cefotaxime S /R> Ceftriaxone S /R> Ceftazidime S /R> Cefepime S /R> CLSI 8/8 1/2 1/2 4/8 8/16 EUCAST 8/8 1/2 1/2 1/8 a 1/8 a EUCAST PK/PD 4/8 1/2 1/2 4/8 4/8 a Ceftazidime and cefepime S breakpoints were adjusted from 4 to 1 ug/ml to ensure that Enterobacteriaceae with clinically important ESBLs were not reported as susceptible Kahlmeter G Clin Microbiol Infect. 2008 Jan;14 Suppl 1:169-74. Review 29
Page 1 and 2: Changing MIC Breakpoints: Do Mechan
Page 3 and 4: • The major issue is whether the
Page 5 and 6: CLSI Guidelines Staph spp. Table 2
Page 7 and 8: New CLSI Guidelines 2010 • This d
Page 9 and 10: Clinical Studies • No randomized
Page 11 and 12: New CLSI Guidelines 2010 • Proble
Page 13 and 14: MICs in g/ml: SHV-3 producing Citro
Page 15 and 16: Efficacy of different beta-lactams
Page 21 and 22: CAP Survey D-C 2007 D-19 C. freundi
Page 23 and 24: New CLSI Guidelines 2010 • Proble
Page 25 and 26: MIC Reproducibility • In this imp
Page 27: Enterobacteriaceae Revised Breakpoi
Page 31: New CLSI Guidelines 2010 • Proble
Page 34 and 35: Why labs should continue to perform
Page 36 and 37: Are the New CLSI Breakpoints the Co
Page 38 and 39: Something to Think About • Breakp
Page 40 and 41: Something to Think About • Antibi
Page 42 and 43: Personalized Antibiotic Report •
Page 44 and 45: Personalized Antibiotic Report •
Page 46: Are the New CLSI Breakpoints the Co

Changing MIC Breakpoints: Do Mechanisms Count

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