Changing MIC Breakpoints: Do Mechanisms Count
Changing MIC Breakpoints: Do Mechanisms Count
Changing MIC Breakpoints: Do Mechanisms Count
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<strong>MIC</strong> Reproducibility<br />
• In this imperfect reality an ESBL producer<br />
with a cefotaxime <strong>MIC</strong> of 1 g/mL (probably<br />
responsive to cefotaxime in vivo) cannot be<br />
reliably distinguished from one with an <strong>MIC</strong> of<br />
4 g/mL (probably not responsive) and it is<br />
simpler and safer to follow the precautionary<br />
approach of seeking the ESBL and, if found,<br />
reporting the isolate as resistant<br />
- David Livermore, 20 th European Congress of<br />
Clinical Microbiology and Infectious Diseases,<br />
Vienna, Austria, 10-13 April, 2010.<br />
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