Changing MIC Breakpoints: Do Mechanisms Count
Changing MIC Breakpoints: Do Mechanisms Count Changing MIC Breakpoints: Do Mechanisms Count
CLSI Acceptable Limits ( g/mL) for QC Strains Used to Monitor Accuracy Antimicrobial E. Coli ATCC 25922 No. of Doubling Dilutions Allowed Cefazolin 1-4 3 Cefotaxime 0.03-0.12 3 Ceftriaxone 0.03-0.12 3 Ceftazidime 0.06-0.5 4 Aztreonam 0.06-0.25 3 Cefepime 0.015-0.12 8 CLSI M100-S20. Table 4 24
MIC Reproducibility • In this imperfect reality an ESBL producer with a cefotaxime MIC of 1 g/mL (probably responsive to cefotaxime in vivo) cannot be reliably distinguished from one with an MIC of 4 g/mL (probably not responsive) and it is simpler and safer to follow the precautionary approach of seeking the ESBL and, if found, reporting the isolate as resistant - David Livermore, 20 th European Congress of Clinical Microbiology and Infectious Diseases, Vienna, Austria, 10-13 April, 2010. 25
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CLSI Acceptable Limits ( g/mL) for QC<br />
Strains Used to Monitor Accuracy<br />
Antimicrobial E. Coli ATCC 25922 No. of <strong>Do</strong>ubling<br />
Dilutions Allowed<br />
Cefazolin 1-4 3<br />
Cefotaxime 0.03-0.12 3<br />
Ceftriaxone 0.03-0.12 3<br />
Ceftazidime 0.06-0.5 4<br />
Aztreonam 0.06-0.25 3<br />
Cefepime 0.015-0.12 8<br />
CLSI M100-S20. Table 4<br />
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